Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina

Highlights ► Vaccination with tick subolesin controls Rhipicephalus (Boophilus) microplus infestations in cattle. ► Ticks fed on vaccinated cattle show lower subolesin mRNA levels when compared to controls, resembling RNAi results. ► Anaplasma marginale and Babesia bigemina infection decrease in tic...

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Bibliographic Details
Published in:Vaccine 2011-11, Vol.29 (47), p.8575-8579
Main Authors: Merino, Octavio, Almazán, Consuelo, Canales, Mario, Villar, Margarita, Moreno-Cid, Juan A, Galindo, Ruth C, de la Fuente, José
Format: Article
Language:English
Subjects:
Akirin
Allergy and Immunology
Anaplasma marginale
Anaplasma marginale - genetics
Anaplasma marginale - isolation & purification
Animals
antigens
Antigens - biosynthesis
Antigens - immunology
Applied microbiology
Arthropod Proteins - antagonists & inhibitors
Arthropod Proteins - biosynthesis
Arthropod Proteins - immunology
Babesia - genetics
Babesia - isolation & purification
Babesia bigemina
Bacteriology
Biological and medical sciences
Boophilus
Boophilus microplus
Cattle
Cattle tick
disease transmission
Female
Fundamental and applied biological sciences. Psychology
gene expression
Gene Expression Profiling
genes
Ixodidae
larvae
messenger RNA
Microbiology
Miscellaneous
pathogens
Polymerase Chain Reaction
Rhipicephalus
Rhipicephalus - immunology
Rhipicephalus - microbiology
Rhipicephalus - parasitology
RNA interference
salivary glands
Subolesin
tick control
tick infestations
Tick Infestations - prevention & control
ticks
vaccination
Vaccine
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vector
vector control
vector vaccines
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Description
Summary:Highlights ► Vaccination with tick subolesin controls Rhipicephalus (Boophilus) microplus infestations in cattle. ► Ticks fed on vaccinated cattle show lower subolesin mRNA levels when compared to controls, resembling RNAi results. ► Anaplasma marginale and Babesia bigemina infection decrease in ticks fed on vaccinated cattle and after subolesin knockdown. ► Targeting subolesin expression by vaccination or RNAi results in lower tick subolesin mRNA and pathogen infection levels.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.09.023