Antifungal metabolites from Chaetomium globosum, an endophytic fungus in Ginkgo biloba

From the culture of an endophyte Chaetomium globosum found in Ginkgo biloba, twelve metabolites, including three diketopiperazines, two cytochalasins, two sterols, two simple phenolic compounds, one complex aromatic compound, a nonprotein amino acid and a linear triterpene were isolated. Of them, ei...

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Bibliographic Details
Published in:Biochemical systematics and ecology 2011-08, Vol.39 (4-6), p.876-879
Main Authors: Li, Hu-Qiang, Li, Xiao-Jun, Wang, You-Lin, Zhang, Qiang, Zhang, An-Ling, Gao, Jin-Ming, Zhang, Xing-Chang
Format: Article
Language:English
Subjects:
Antifungal activity
Chaetomium globosum
Endophytic fungus
Epipolythiodioxopiperazine
Ginkgo biloba
Gliotoxin
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Summary:From the culture of an endophyte Chaetomium globosum found in Ginkgo biloba, twelve metabolites, including three diketopiperazines, two cytochalasins, two sterols, two simple phenolic compounds, one complex aromatic compound, a nonprotein amino acid and a linear triterpene were isolated. Of them, eight compounds are first reported for the genus Chaetomium. Gliotoxin (8) has good antifungal activity against plant pathogenic fungi. [Display omitted] ► Twelve compounds were isolated from an endophyte C. globosum harboring inside G. biloba leaves. ► Eight compounds are new for the genus Chaetomium. ► Gliotoxin (8) possessed good antifungal activity against some phytopathogenic fungi.
ISSN:0305-1978
1873-2925
DOI:10.1016/j.bse.2011.06.019