Prevalence of antibodies to hepatitis B core antigen and occult hepatitis B virus infections in Korean blood donors

BACKGROUND: This study was performed to determine the prevalence of antibodies to hepatitis B core antigen (anti‐HBc) among Korean blood donors and frequencies of hepatitis B virus (HBV) DNA and antibodies to hepatitis B surface antigen (anti‐HBs) in anti‐HBc–positive donors. STUDY DESIGN AND METHOD...

Full description

Saved in:
Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2011-08, Vol.51 (8), p.1840-1846
Main Authors: Seo, Dong Hee, Whang, Dong Hee, Song, Eun Young, Kim, Hyun Soo, Park, Quehn
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Asymptomatic Infections - epidemiology
Biological and medical sciences
Blood Donors - statistics & numerical data
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Female
Hepatitis B - blood
Hepatitis B - epidemiology
Hepatitis B - immunology
Hepatitis B Antibodies - blood
Hepatitis B Core Antigens - immunology
Hepatitis B virus
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Prevalence
Republic of Korea - epidemiology
Seroepidemiologic Studies
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Viral diseases
Viral hepatitis
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: This study was performed to determine the prevalence of antibodies to hepatitis B core antigen (anti‐HBc) among Korean blood donors and frequencies of hepatitis B virus (HBV) DNA and antibodies to hepatitis B surface antigen (anti‐HBs) in anti‐HBc–positive donors. STUDY DESIGN AND METHODS: A total of 12,461 consenting blood donors were consecutively enrolled from Korean Red Cross Blood Services from April to October 2008. All of the donors were screened for anti‐HBc with an electrochemiluminescence immunoassay. Repeat‐reactive anti‐HBc–positive donors were assayed for anti‐HBs and for HBV DNA using a multiplex test (Cobas TaqScreen, Roche Molecular Systems) on individual donation. RESULTS: Of the 12,461 donors, 1682 (13.5%) were reactive for anti‐HBc. Among different age groups, there was a steady increase in the anti‐HBc–positive rate, ranging from 2.0% in the age group of less than 20 years to 80.0% in the age group of 60 years and older (p 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2010.03056.x