Synthesis and antiviral activity of 18 Delta a-glycyrrhizic acid and its esters

New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18 Delta *a-glycyrrhizic acid (18 Delta *a-GA) were synthesized; these were D/E-trans-isomers of natural 18 Delta *b-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2010-10, Vol.44 (6), p.299-302
Main Authors: Baltina, L A, Stolyarova, O V, Kondratenko, R M, Plyasunova, O A, Pokrovskii, A G
Format: Article
Language:English
Subjects:
Glycyrrhiza glabra
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Summary:New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18 Delta *a-glycyrrhizic acid (18 Delta *a-GA) were synthesized; these were D/E-trans-isomers of natural 18 Delta *b-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L. and Gl. uralensis Fisher). Changes in the stereochemistry of the GA aglycone led to significant decreases in its anti-HIV-1 activity.
ISSN:0091-150X
DOI:10.1007/s11094-010-0454-1