Synthesis and antifungal and antibacterial activity of hexahydronicotine derivatives

Acylation of hexahydronicotine with anhydrides of dicarboxylic acids yielded amido acids. Reaction of amido acids with amines, ethanol, and hydrazine produced derivatives. Studies of these compounds showed them to have antifungal and antibacterial activity.

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Published in:Pharmaceutical chemistry journal 2008-04, Vol.42 (4), p.180-182, Article 180
Main Authors: Kagarlitskii, A. D., Krichevskii, L. A., Astaf’eva, Z. M., Akhmetova, S. B., Seidakhmetova, R. B., Drab, A. I.
Format: Article
Language:English
Subjects:
Acids
Acylation
amines
Antibacterial activity
Antifungal agents
Ethanol
Hydrazine
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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container_title Pharmaceutical chemistry journal
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creator Kagarlitskii, A. D.
Krichevskii, L. A.
Astaf’eva, Z. M.
Akhmetova, S. B.
Seidakhmetova, R. B.
Drab, A. I.
description Acylation of hexahydronicotine with anhydrides of dicarboxylic acids yielded amido acids. Reaction of amido acids with amines, ethanol, and hydrazine produced derivatives. Studies of these compounds showed them to have antifungal and antibacterial activity.
doi_str_mv 10.1007/s11094-008-0098-6
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issn 0091-150X
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source Springer Nature
subjects Acids
Acylation
amines
Antibacterial activity
Antifungal agents
Ethanol
Hydrazine
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
title Synthesis and antifungal and antibacterial activity of hexahydronicotine derivatives
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