Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review

Hereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56‐year‐old Asian female. Progressive iron...

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Bibliographic Details
Published in:Liver international 2011-11, Vol.31 (10), p.1589-1592
Main Authors: Dwyer, Jeremy P., Sarwar, Shahzad, Egan, Brian, Nolan, Niamh, Hegarty, John
Format: Article
Language:English
Subjects:
Amino Acid Substitution - genetics
Biopsy, Needle
Female
Ferritins - blood
Hemochromatosis - genetics
Hemochromatosis Protein
hereditary haemochromatosis
HFE mutation
Histocompatibility Antigens Class I - genetics
Homeostasis - physiology
Humans
Iron - metabolism
iron overload
liver transplantation
Liver Transplantation - adverse effects
Membrane Proteins - genetics
Middle Aged
Necrosis - etiology
Phlebotomy - methods
Tissue Donors
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Summary:Hereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56‐year‐old Asian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis.
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2011.02606.x