Signal profile on Gd-EOB-DTPA-enhanced MR imaging in non-alcoholic steatohepatitis and liver cirrhosis induced in rats: correlation with transporter expression

• Published in: European radiology 2011-12, Vol.21 (12), p.2542-2550
• Main Authors: Tsuda, Natsuko, Matsui, Osamu
• Format: Article
• Language: English
• Subjects: Animals; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Contrast agents; Contrast Media; Diagnostic Radiology; Fatty Liver - diagnosis; Fatty Liver - genetics; Fatty Liver - metabolism; Gadolinium DTPA; Image Processing, Computer-Assisted; Imaging; Internal Medicine; Interventional Radiology; Liver cancer; Liver cirrhosis; Liver Cirrhosis, Experimental - diagnosis; Liver Cirrhosis, Experimental - metabolism; Liver diseases; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Metabolism; Neuroradiology; Non-alcoholic Fatty Liver Disease; Organic Anion Transporters, Sodium-Independent - genetics; Organic Anion Transporters, Sodium-Independent - metabolism; Radiology; Rats; Rats, Wistar; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-011-2228-x

Objectives To compare the transporter expression and signal profile on Gd-EOB-DTPA-enhanced MRI between non-alcoholic steatohepatitis (NASH) and cirrhotic liver induced in rats, and investigate the correlation of the transporter expression and fibrosis rate in both diseases. Methods Forty-eight rats were divided into four groups of 12: TAA (cirrhosis), NASH 7- and 10-week, and control groups. Each group was divided into two subgroups: Group 1 for MRI and Group 2 for transporter examinations. Results The relative enhancement of the TAA group was significantly lower than those of other groups ( p