Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults

Objectives To determine whether zolpidem is a safer alternative to benzodiazepines. Design Retrospective cohort study. Setting Community based. Participants Health maintenance organization members with an initial prescription for zolpidem (n = 43,343), alprazolam (n = 103,790), lorazepam (n = 150,85...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2011-10, Vol.59 (10), p.1883-1890
Main Authors: Finkle, William D., Der, Jane S., Greenland, Sander, Adams, John L., Ridgeway, Gregory, Blaschke, Terrance, Wang, Zixia, Dell, Richard M., VanRiper, Kurt B.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alprazolam - adverse effects
Alprazolam - therapeutic use
benzodiazepines
Biological and medical sciences
Causality
Cohort Studies
Comparative studies
Cross-Sectional Studies
Diazepam - adverse effects
Diazepam - therapeutic use
Female
Fractures
Fractures, Bone - epidemiology
General aspects
Health Surveys
Hip Fractures - epidemiology
Hospitalization
Hospitalization - statistics & numerical data
Humans
Hypnotics and Sedatives - adverse effects
Hypnotics and Sedatives - therapeutic use
injury
Joint Dislocations - epidemiology
Lorazepam - adverse effects
Lorazepam - therapeutic use
Male
Medical sciences
Miscellaneous
Odds Ratio
Older people
Psychotropic drugs
Public health. Hygiene
Public health. Hygiene-occupational medicine
Pyridines - adverse effects
Pyridines - therapeutic use
Retrospective Studies
Risk
Risk factors
Statistics as Topic
zolpidem
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To determine whether zolpidem is a safer alternative to benzodiazepines. Design Retrospective cohort study. Setting Community based. Participants Health maintenance organization members with an initial prescription for zolpidem (n = 43,343), alprazolam (n = 103,790), lorazepam (n = 150,858), or diazepam (n = 93,618). Measurements Zolpidem and benzodiazepine prescriptions were identified from pharmacy databases. Rates of nonvertebral fractures and hip fractures requiring hospitalization were compared before and after an initial prescription for each treatment, adjusting for confounders using doubly robust estimation. Results In patients aged 65 and older, the rates of nonvertebral fractures and dislocations were similar in the pre‐ treatment intervals. The rate ratios (RRs) for the 90‐day posttreatment interval relative to the pretreatment interval were 2.55 (95% confidence interval (CI) = 1.78–3.65; P 
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2011.03591.x