The effect of water-soluble polymers, PEG and PVP, on the solubilisation of griseofulvin in aqueous micellar solutions of Pluronic F127

The purpose of this study was to investigate the possibility of enhancing the solubilisation capacity of micellar solutions of Pluronic F127 for the poorly water-soluble drug griseofulvin by co-formulating with a water-soluble polymer. The effect of the addition of the polyethylene glycols PEG6000 a...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2011-12, Vol.421 (2), p.252-257
Main Authors: Oliveira, Cristiane P., Ribeiro, Maria Elenir N.P., Ricardo, Nágila M.P.S., Souza, Ticiane V. de P., Moura, Carolina Lima, Chaibundit, Chiraphon, Yeates, Stephen G., Nixon, Keith, Attwood, David
Format: Article
Language:English
Subjects:
additives
Antifungal Agents - chemistry
Biological and medical sciences
drugs
General pharmacology
griseofulvin
Griseofulvin - chemistry
Hydrophobic and Hydrophilic Interactions
light scattering
Medical sciences
Micelles
particle size
PEG
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pluronic F127
polyethylene glycol
Polyethylene Glycols - chemistry
Polyvinyls - chemistry
PVP
Pyrrolidines - chemistry
Solubilisation
Solubility
solubilization
Water
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to investigate the possibility of enhancing the solubilisation capacity of micellar solutions of Pluronic F127 for the poorly water-soluble drug griseofulvin by co-formulating with a water-soluble polymer. The effect of the addition of the polyethylene glycols PEG6000 and 35000, and the poly(vinylpyrrolidone)s PVP K30 and K90, on the solubilisation capacity of 1wt% solutions of Pluronic F127 was related to the effect of these additives on particle size as determined by dynamic light scattering measurements. The addition of PEG35000 to 1wt% F127 solutions significantly increased the solubility capacity expressed in terms of unit weight of F127; PVP K90 had a smaller effect but no enhancement was noted following the addition of PEG6000 or PVP K30. Solubilisation enhancement was thought to be a consequence of the association of the polymers with the E-blocks of the micelle corona so providing an expanded region of reduced polarity for drug solubilisation.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.10.010