Lesional Th17 cells and regulatory T cells in bullous pemphigoid

:  Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigo...

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Bibliographic Details
Published in:Experimental dermatology 2011-12, Vol.20 (12), p.1022-1024
Main Authors: Arakawa, Masataka, Dainichi, Teruki, Ishii, Norito, Hamada, Takahiro, Karashima, Tadashi, Nakama, Takekuni, Yasumoto, Shinichiro, Tsuruta, Daisuke, Hashimoto, Takashi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Autoimmune diseases
Biological and medical sciences
Blister - immunology
Blister - pathology
Bullous diseases of the skin
Bullous pemphigoid
CD4 antigen
Dermatology
Female
Forkhead Transcription Factors - metabolism
Foxp3 protein
Helper cells
Humans
IL-17
Immunoregulation
Inflammation
Interleukin 17
Interleukin-17 - blood
Interleukin-17 - metabolism
Lymphocytes T
Male
Medical sciences
Middle Aged
Pemphigoid, Bullous - blood
Pemphigoid, Bullous - immunology
Pemphigoid, Bullous - pathology
Pemphigus - immunology
Pemphigus - pathology
Pemphigus foliaceus
pemphigus vulgaris
Skin diseases
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
T-Lymphocytes, Regulatory - pathology
Th17
Th17 Cells - immunology
Th17 Cells - metabolism
Th17 Cells - pathology
Treg
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Summary::  Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations between these cells and disease severity of BP were also evaluated. Immunohistochemical studies showed that both IL‐17+ and Foxp3+ cells were present in higher numbers in BP lesions, compared with control skin. IL‐17/CD4 ratio in BP was significantly higher than that in PF. Foxp3/CD4 ratio in BP was significantly less than that in either PV or PF. There were no obvious correlations between these cells and disease severity of BP. This study suggests that, compared with pemphigus, BP shows more Th17 cell‐related inflammation and less Treg‐related regulation.
ISSN:0906-6705
1600-0625
DOI:10.1111/j.1600-0625.2011.01378.x