Innate immunity in the pathogenesis of psoriasis

Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The...

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Bibliographic Details
Published in:Archives of Dermatological Research 2011-12, Vol.303 (10), p.691-705
Main Authors: Sweeney, Cheryl M., Tobin, Ann-Marie, Kirby, Brian
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Biological and medical sciences
Cell proliferation
Cytokines
Cytokines - immunology
Dermatology
Helper cells
Humans
Immune response
Immunity
Immunity, Innate
Infection
Inflammation
Inflammatory diseases
Keratinocytes
Lymphocytes
Lymphocytes T
Medical sciences
Medicine
Medicine & Public Health
Plaques
Psoriasis
Psoriasis - immunology
Psoriasis. Parapsoriasis. Lichen
Review Article
Signal transduction
Signal Transduction - immunology
Skin
Skin - immunology
Th1 Cells - immunology
Th17 Cells - immunology
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Summary:Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-011-1169-1