Association Between the Secretory Unit of Islet Transplant Objects Index and Satisfaction With Insulin Therapy Among Insulin-Dependent Islet Recipients

Abstract Introduction When patients do not become insulin independent after islet cell transplantation (ICT), another aim is to eliminate severe hypoglycemia. Previously we reported that a secretory unit of islet transplant objects (SUITO) index score >10 was associated with a reduction of severe...

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Bibliographic Details
Published in:Transplantation proceedings 2011-11, Vol.43 (9), p.3250-3255
Main Authors: Takita, M, Matsumoto, S, Shimoda, M, Chujo, D, Itoh, T, Iwahashi, S, SoRelle, J.A, Onaca, N, Naziruddin, B, Levy, M.F
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - metabolism
C-Peptide - metabolism
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - therapy
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Survival
Humans
Hypoglycemia - therapy
Insulin - metabolism
Insulin - therapeutic use
Islets of Langerhans - cytology
Islets of Langerhans Transplantation - methods
Islets of Langerhans Transplantation - standards
Male
Medical sciences
Middle Aged
Outpatients
Patient Satisfaction
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surveys and Questionnaires
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract Introduction When patients do not become insulin independent after islet cell transplantation (ICT), another aim is to eliminate severe hypoglycemia. Previously we reported that a secretory unit of islet transplant objects (SUITO) index score >10 was associated with a reduction of severe hypoglycemia. In this study, we assessed patients' satisfaction with their insulin therapy based on the SUITO index. Methods The study involved 11 islet recipients with type 1 diabetes who underwent ICT but still used insulin. From those patients, 41 Insulin Therapy Satisfaction Questionnaires (ITSQ) were collected. The SUITO index (fasting C-peptide [ng/mL] × 1500/blood glucose [mg/dL] − 63) was calculated at the same outpatient visits that the survey was administered. ITSQ scores were summarized using subscales and compared among 3 groups: the pre-ICT group, the low-SUITO group (SUITO index score
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.10.029