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Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease
To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD. Patients with ≥ 70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' de...
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| Published in: | Clinical biochemistry 2011-12, Vol.44 (17), p.1421-1424 |
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| cites | cdi_FETCH-LOGICAL-c406t-b17d9307556f6a2f941da34766f9a53cc8eb5f83121a0bcd49385f01b3313f5d3 |
| container_end_page | 1424 |
| container_issue | 17 |
| container_start_page | 1421 |
| container_title | Clinical biochemistry |
| container_volume | 44 |
| creator | Alidoosti, Mohammad Ghaedi, Mahboobeh Soleimani, Abbas Bakhtiyari, Salar Rezvanfard, Mehrnaz Golkhu, Shekufeh Mohammadtaghvaei, Narges |
| description | To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD.
Patients with ≥
70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).
There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR
=
1.026, 95%, CI: 1.02–0.04, p
<
0.001), whereas aging and cigarette smoking were negative predictors (OR
=
0.95, 95% CI: 0.91–0.99, p
<
0.05; OR
=
0.30, 95% CI: 0.11–0.79, p <
0.05; respectively).
The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia |
| doi_str_mv | 10.1016/j.clinbiochem.2011.09.001 |
| format | article |
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Patients with ≥
70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).
There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR
=
1.026, 95%, CI: 1.02–0.04, p
<
0.001), whereas aging and cigarette smoking were negative predictors (OR
=
0.95, 95% CI: 0.91–0.99, p
<
0.05; OR
=
0.30, 95% CI: 0.11–0.79, p <
0.05; respectively).
The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2011.09.001</identifier><identifier>PMID: 21945026</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Aged ; Amino Acid Substitution ; Biological and medical sciences ; Cardiology. Vascular system ; Collateral Circulation - genetics ; Coronary Angiography ; Coronary collateral formation ; Coronary heart disease ; Environmental Exposure - adverse effects ; Female ; Genetic Association Studies ; Genotype ; Heart ; Humans ; Hypoxia-inducible factor 1 (HIF-1) ; Hypoxia-Inducible Factor 1, alpha Subunit - genetics ; Investigative techniques, diagnostic techniques (general aspects) ; Iranian population ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Myocardial Ischemia - diagnostic imaging ; Myocardial Ischemia - etiology ; Myocardial Ischemia - genetics ; Myocarditis. Cardiomyopathies ; Neovascularization, Physiologic - genetics ; Polymorphism ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA</subject><ispartof>Clinical biochemistry, 2011-12, Vol.44 (17), p.1421-1424</ispartof><rights>2011 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-b17d9307556f6a2f941da34766f9a53cc8eb5f83121a0bcd49385f01b3313f5d3</citedby><cites>FETCH-LOGICAL-c406t-b17d9307556f6a2f941da34766f9a53cc8eb5f83121a0bcd49385f01b3313f5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25305558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21945026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alidoosti, Mohammad</creatorcontrib><creatorcontrib>Ghaedi, Mahboobeh</creatorcontrib><creatorcontrib>Soleimani, Abbas</creatorcontrib><creatorcontrib>Bakhtiyari, Salar</creatorcontrib><creatorcontrib>Rezvanfard, Mehrnaz</creatorcontrib><creatorcontrib>Golkhu, Shekufeh</creatorcontrib><creatorcontrib>Mohammadtaghvaei, Narges</creatorcontrib><title>Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD.
Patients with ≥
70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).
There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR
=
1.026, 95%, CI: 1.02–0.04, p
<
0.001), whereas aging and cigarette smoking were negative predictors (OR
=
0.95, 95% CI: 0.91–0.99, p
<
0.05; OR
=
0.30, 95% CI: 0.11–0.79, p <
0.05; respectively).
The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia</description><subject>Aged</subject><subject>Amino Acid Substitution</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Collateral Circulation - genetics</subject><subject>Coronary Angiography</subject><subject>Coronary collateral formation</subject><subject>Coronary heart disease</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypoxia-inducible factor 1 (HIF-1)</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iranian population</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - etiology</subject><subject>Myocardial Ischemia - genetics</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Neovascularization, Physiologic - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sequence Analysis, DNA</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNkc2OFCEUhStG4_SMvoLBhXFVLRQFXSwnHecnmcSFuiYUXKboFFACPZN-EZ9XOt3-LF1xSb5z77n3NM17gtcEE_5pt9azC6OLegK_7jAhayzWGJMXzYoMG9p2gtKXzQpjLFpBOnzRXOa8q9-uH_jr5qIjome446vm59eyNwcUAyoToBRnQNEiCE8uxeAhFDWjRSXloUDKSAWD7u5vWnKNHiEAWuJ88DEtk8seuYB0rDKVDrWYZ1UlVW5j8qq4OkL5GB5ru-Jq44yeXZmQy8clnEYTqFSQcRlUhjfNK6vmDG_P71Xz_ebzt-1d-_Dl9n57_dDqHvPSjmRjBMUbxrjlqrOiJ0bRfsO5FYpRrQcYmR0o6YjCoza9oAOzmIyUEmqZoVfNx1PfJcUfe8hF-moIqvcAcZ-lwIwPFPe8kuJE6hRzTmDlkpyvq0qC5TEVuZP_pCKPqUgsZE2lat-dp-xHD-aP8ncMFfhwBlTWarZJBe3yX45RzBgbKrc9cVBv8uQgyazrLTUYl0AXaaL7Dzu_AOoes5s</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Alidoosti, Mohammad</creator><creator>Ghaedi, Mahboobeh</creator><creator>Soleimani, Abbas</creator><creator>Bakhtiyari, Salar</creator><creator>Rezvanfard, Mehrnaz</creator><creator>Golkhu, Shekufeh</creator><creator>Mohammadtaghvaei, Narges</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease</title><author>Alidoosti, Mohammad ; Ghaedi, Mahboobeh ; Soleimani, Abbas ; Bakhtiyari, Salar ; Rezvanfard, Mehrnaz ; Golkhu, Shekufeh ; Mohammadtaghvaei, Narges</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-b17d9307556f6a2f941da34766f9a53cc8eb5f83121a0bcd49385f01b3313f5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Amino Acid Substitution</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Collateral Circulation - genetics</topic><topic>Coronary Angiography</topic><topic>Coronary collateral formation</topic><topic>Coronary heart disease</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypoxia-inducible factor 1 (HIF-1)</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iranian population</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Myocardial Ischemia - etiology</topic><topic>Myocardial Ischemia - genetics</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Neovascularization, Physiologic - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sequence Analysis, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alidoosti, Mohammad</creatorcontrib><creatorcontrib>Ghaedi, Mahboobeh</creatorcontrib><creatorcontrib>Soleimani, Abbas</creatorcontrib><creatorcontrib>Bakhtiyari, Salar</creatorcontrib><creatorcontrib>Rezvanfard, Mehrnaz</creatorcontrib><creatorcontrib>Golkhu, Shekufeh</creatorcontrib><creatorcontrib>Mohammadtaghvaei, Narges</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alidoosti, Mohammad</au><au>Ghaedi, Mahboobeh</au><au>Soleimani, Abbas</au><au>Bakhtiyari, Salar</au><au>Rezvanfard, Mehrnaz</au><au>Golkhu, Shekufeh</au><au>Mohammadtaghvaei, Narges</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>44</volume><issue>17</issue><spage>1421</spage><epage>1424</epage><pages>1421-1424</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD.
Patients with ≥
70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).
There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR
=
1.026, 95%, CI: 1.02–0.04, p
<
0.001), whereas aging and cigarette smoking were negative predictors (OR
=
0.95, 95% CI: 0.91–0.99, p
<
0.05; OR
=
0.30, 95% CI: 0.11–0.79, p <
0.05; respectively).
The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21945026</pmid><doi>10.1016/j.clinbiochem.2011.09.001</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical biochemistry, 2011-12, Vol.44 (17), p.1421-1424 |
| issn | 0009-9120 1873-2933 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Aged Amino Acid Substitution Biological and medical sciences Cardiology. Vascular system Collateral Circulation - genetics Coronary Angiography Coronary collateral formation Coronary heart disease Environmental Exposure - adverse effects Female Genetic Association Studies Genotype Heart Humans Hypoxia-inducible factor 1 (HIF-1) Hypoxia-Inducible Factor 1, alpha Subunit - genetics Investigative techniques, diagnostic techniques (general aspects) Iranian population Male Medical sciences Middle Aged Multivariate Analysis Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - etiology Myocardial Ischemia - genetics Myocarditis. Cardiomyopathies Neovascularization, Physiologic - genetics Polymorphism Polymorphism, Single Nucleotide Sequence Analysis, DNA |
| title | Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease |
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