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Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults
Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species, which results in damage to cells or tissues. Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, d...
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| Published in: | Phytotherapy research 2011-12, Vol.25 (12), p.1813-1818 |
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| cites | cdi_FETCH-LOGICAL-c4874-aa36915daffca269ac8506d4fa76caf5924eaa865b44126adb23c2b49a3644e3 |
| container_end_page | 1818 |
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| creator | Choi, Hye Duck Kim, Ji Hae Chang, Min Jung Kyu-Youn, Yeo Shin, Wan Gyoon |
| description | Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species, which results in damage to cells or tissues. Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, double‐blind study was performed to investigate the effect of astaxanthin (ASX), which is known to be a potent antioxidant, on oxidative stress in overweight and obese adults in Korea. Twenty‐three adults with BMI > 25.0 kg/m2 enrolled in this study and were randomly assigned to two dose groups: ASX 5 mg and 20 mg once daily for 3 weeks. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and 1, 2 and 3 weeks after ASX administration. Compared with baseline, the MDA (by 34.6% and 35.2%) and ISP (by 64.9% and 64.7%) levels were significantly lowered, whereas SOD (by 193% and 194%) and TAC (by 121% and 125%) levels were significantly increased in two dose groups after the 3 week intervention. This study revealed that supplemental ASX for 3 weeks improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the activity of the antioxidant defense system. Copyright © 2011 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.3494 |
| format | article |
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Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, double‐blind study was performed to investigate the effect of astaxanthin (ASX), which is known to be a potent antioxidant, on oxidative stress in overweight and obese adults in Korea. Twenty‐three adults with BMI > 25.0 kg/m2 enrolled in this study and were randomly assigned to two dose groups: ASX 5 mg and 20 mg once daily for 3 weeks. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and 1, 2 and 3 weeks after ASX administration. Compared with baseline, the MDA (by 34.6% and 35.2%) and ISP (by 64.9% and 64.7%) levels were significantly lowered, whereas SOD (by 193% and 194%) and TAC (by 121% and 125%) levels were significantly increased in two dose groups after the 3 week intervention. This study revealed that supplemental ASX for 3 weeks improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the activity of the antioxidant defense system. Copyright © 2011 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>ISSN: 1099-1573</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3494</identifier><identifier>PMID: 21480416</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; antioxidant ; Antioxidants - pharmacology ; astaxanthin ; Biological and medical sciences ; Biomarkers - blood ; Diet ; Double-Blind Method ; Female ; General pharmacology ; Humans ; Isoprostanes - analysis ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Male ; Malondialdehyde - analysis ; Medical sciences ; Obesity - blood ; Overweight - blood ; overweight and obesity ; oxidative stress ; Oxidative Stress - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Prospective Studies ; Superoxide Dismutase - analysis ; Xanthophylls - administration & dosage ; Xanthophylls - blood ; Xanthophylls - pharmacology ; Young Adult</subject><ispartof>Phytotherapy research, 2011-12, Vol.25 (12), p.1813-1818</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4874-aa36915daffca269ac8506d4fa76caf5924eaa865b44126adb23c2b49a3644e3</citedby><cites>FETCH-LOGICAL-c4874-aa36915daffca269ac8506d4fa76caf5924eaa865b44126adb23c2b49a3644e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25274368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21480416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Hye Duck</creatorcontrib><creatorcontrib>Kim, Ji Hae</creatorcontrib><creatorcontrib>Chang, Min Jung</creatorcontrib><creatorcontrib>Kyu-Youn, Yeo</creatorcontrib><creatorcontrib>Shin, Wan Gyoon</creatorcontrib><title>Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species, which results in damage to cells or tissues. Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, double‐blind study was performed to investigate the effect of astaxanthin (ASX), which is known to be a potent antioxidant, on oxidative stress in overweight and obese adults in Korea. Twenty‐three adults with BMI > 25.0 kg/m2 enrolled in this study and were randomly assigned to two dose groups: ASX 5 mg and 20 mg once daily for 3 weeks. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and 1, 2 and 3 weeks after ASX administration. Compared with baseline, the MDA (by 34.6% and 35.2%) and ISP (by 64.9% and 64.7%) levels were significantly lowered, whereas SOD (by 193% and 194%) and TAC (by 121% and 125%) levels were significantly increased in two dose groups after the 3 week intervention. This study revealed that supplemental ASX for 3 weeks improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the activity of the antioxidant defense system. Copyright © 2011 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>antioxidant</subject><subject>Antioxidants - pharmacology</subject><subject>astaxanthin</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Diet</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Isoprostanes - analysis</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>Obesity - blood</subject><subject>Overweight - blood</subject><subject>overweight and obesity</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Superoxide Dismutase - analysis</subject><subject>Xanthophylls - administration & dosage</subject><subject>Xanthophylls - blood</subject><subject>Xanthophylls - pharmacology</subject><subject>Young Adult</subject><issn>0951-418X</issn><issn>1099-1573</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp90N9PFDEQB_DGaORAE_8C0xcjLwv9ve3jBQGJhPPHJRpfmtluK9W93aPtwfHfu4QFnvRpkslnZjJfhN5QckAJYYfrkg64MOIZmlFiTEVlzZ-jGTGSVoLqHztoN-ffhBDDiHiJdhgVmgiqZujsOATvSsZDwPNcYAt9uYw9Hnq82MYWSrz2-FtJPmc8thfXPt34-OuyYOhbvGh89njebrqSX6EXAbrsX091Dy1PjpdHH6vzxenZ0fy8ckLXogLgylDZQggOmDLgtCSqFQFq5SBIw4QH0Eo2QlCmoG0Yd6wRZpwTwvM99P5-7ToNVxufi13F7HzXQe-HTbaGSF1Tacgo9_8rqTY1r2uu5RN1acg5-WDXKa4g3VpK7F3CdkzY3iU80rfT1k2z8u0jfIh0BO8mANlBFxL0LuYnJ1ktuNKjq-7dTez87T8P2s_Lr9Phycdc_PbRQ_pj1fiHtN8vTi37eSHYpw_KfuF_AS0qoCA</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Choi, Hye Duck</creator><creator>Kim, Ji Hae</creator><creator>Chang, Min Jung</creator><creator>Kyu-Youn, Yeo</creator><creator>Shin, Wan Gyoon</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults</title><author>Choi, Hye Duck ; Kim, Ji Hae ; Chang, Min Jung ; Kyu-Youn, Yeo ; Shin, Wan Gyoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4874-aa36915daffca269ac8506d4fa76caf5924eaa865b44126adb23c2b49a3644e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>antioxidant</topic><topic>Antioxidants - pharmacology</topic><topic>astaxanthin</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Diet</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Isoprostanes - analysis</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>Obesity - blood</topic><topic>Overweight - blood</topic><topic>overweight and obesity</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Superoxide Dismutase - analysis</topic><topic>Xanthophylls - administration & dosage</topic><topic>Xanthophylls - blood</topic><topic>Xanthophylls - pharmacology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Hye Duck</creatorcontrib><creatorcontrib>Kim, Ji Hae</creatorcontrib><creatorcontrib>Chang, Min Jung</creatorcontrib><creatorcontrib>Kyu-Youn, Yeo</creatorcontrib><creatorcontrib>Shin, Wan Gyoon</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Hye Duck</au><au>Kim, Ji Hae</au><au>Chang, Min Jung</au><au>Kyu-Youn, Yeo</au><au>Shin, Wan Gyoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and 1, 2 and 3 weeks after ASX administration. Compared with baseline, the MDA (by 34.6% and 35.2%) and ISP (by 64.9% and 64.7%) levels were significantly lowered, whereas SOD (by 193% and 194%) and TAC (by 121% and 125%) levels were significantly increased in two dose groups after the 3 week intervention. This study revealed that supplemental ASX for 3 weeks improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the activity of the antioxidant defense system. Copyright © 2011 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21480416</pmid><doi>10.1002/ptr.3494</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult antioxidant Antioxidants - pharmacology astaxanthin Biological and medical sciences Biomarkers - blood Diet Double-Blind Method Female General pharmacology Humans Isoprostanes - analysis lipid peroxidation Lipid Peroxidation - drug effects Male Malondialdehyde - analysis Medical sciences Obesity - blood Overweight - blood overweight and obesity oxidative stress Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Prospective Studies Superoxide Dismutase - analysis Xanthophylls - administration & dosage Xanthophylls - blood Xanthophylls - pharmacology Young Adult |
| title | Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults |
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