Synthesis of diaryl ketones via a phosphine-free Fukuyama reaction

The synthesis of unsymmetrical diaryl ketones via the Fukuyama coupling of thioesters and organozinc reagents is described. Typically, the synthesis of diaryl ketones using this methodology provides low yields. The simple complex, Pd(dba)(2), was found to convert a variety of aryl thioesters to diar...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (47), p.12679-12681
Main Authors: Kunchithapatham, Kamala, Eichman, Chad C, Stambuli, James P
Format: Article
Language:English
Subjects:
Aromatic compounds
Joining
Ketones
Methodology
Synthesis
Thioesters
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Summary:The synthesis of unsymmetrical diaryl ketones via the Fukuyama coupling of thioesters and organozinc reagents is described. Typically, the synthesis of diaryl ketones using this methodology provides low yields. The simple complex, Pd(dba)(2), was found to convert a variety of aryl thioesters to diaryl ketones in good yields.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16114h