Synthesis and Characterization of Heteroleptic Copper and Zinc Complexes with Saccharinate and Aminoacids. Evaluation of SOD-like Activity of the Copper Complexes

Five new copper and zinc heteroleptic complexes with saccharin and aminoacids with general stoichiometry Na2[M(sac)2(aa)2][Symbol: see text]nH2O (M denotes Cu or Zn, sac the saccharinate ion, and aa the aminoacids) were synthesized and characterized by elemental and thermogravimetric analysis, condu...

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Bibliographic Details
Published in:Biological trace element research 2011-12, Vol.143 (3), p.1843-1855
Main Authors: Santi, Eduardo, Viera, Inés, Mombrú, Alvaro, Castiglioni, Jorge, Baran, Enrique J, Torre, María H
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - chemistry
Biochemistry
Biomedical and Life Sciences
Biotechnology
Carbohydrates - chemistry
Chemical synthesis
Copper
Copper - chemistry
ions
Life Sciences
nitrogen
Nutrition
Oncology
saccharin
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectrum analysis
Spectrum Analysis, Raman
stoichiometry
Superoxide Dismutase - chemistry
Thermogravimetry
Zinc
Zinc - chemistry
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Summary:Five new copper and zinc heteroleptic complexes with saccharin and aminoacids with general stoichiometry Na2[M(sac)2(aa)2][Symbol: see text]nH2O (M denotes Cu or Zn, sac the saccharinate ion, and aa the aminoacids) were synthesized and characterized by elemental and thermogravimetric analysis, conductimetric measurements and IR, Raman and UV–vis spectroscopies. In all the complexes, copper and zinc ions coordinated with the aminoacids through the terminal amine and carboxylate residues and with saccharin through the heterocyclic nitrogen atom. Besides, the superoxide dismutase-like activity of the heteroleptic copper complexes was evaluated and compared with the homoleptic copper amino acid complexes with the aim to observe the influence of the saccharin coordination.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-011-8992-2