Effect of Different Iodine Nutrition on Cerebellum Pcp-2 in Rat Offspring During Lactation

• Published in: Biological trace element research 2011-12, Vol.143 (3), p.1629-1639
• Main Authors: Zhang, Lu, Sun, Yi Na, Li, Yong Mei, Lin, Lai Xiang, Ye, Yan, Yan, Yu Qin, Chen, Zu Pei
• Format: Article
• Language: English
• Subjects: Animals; Base Sequence; Biochemistry; Biomedical and Life Sciences; Biotechnology; Birth; Breastfeeding & lactation; Central nervous system; cerebellum; Cerebellum - metabolism; DNA Primers; Female; Immunohistochemistry; Iodine; Iodine - administration & dosage; Iodine - deficiency; Lactation; Life Sciences; mammary glands; messenger RNA; neonates; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; neurodevelopment; Nutrient deficiency; Nutrients; Nutrition; Nutritional Status; Offspring; Oncology; postnatal development; progeny; Radioimmunoassay; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger - genetics; Rodents; Thyroid; thyroid function; Thyroid Hormones - blood
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-011-8991-3

The thyroid functions of breastfed infants, as well as (indirectly) the development of their central nervous system, are dependent on the iodine status of the lactating mother. Purkinje cell protein-2 is a cell-specific marker of the cerebellum Purkinje cell and is a suitable indicator for observing the postnatal development of the cerebellum after birth. We measured the Purkinje cell protein-2 mRNA and protein levels in the rat cerebellum in the critical postnatal (14 days after birth) and maturation periods (28 days after birth) to determine the effect of different nutritional iodine levels on cerebellum growth in the offspring during lactation. We found that severe iodine deficiency resulted in thyroid dysfunction in lactating rats and their offspring on both 14 and 28 days, showing maternal total T4 16.7 ± 12.0 vs 36.4 ± 15.0, P