Significance of Pathologic Response to Preoperative Therapy in Pancreatic Cancer

Background Pathologic response to preoperative therapy is increasingly recognized as an important prognostic factor in solid tumors. The impact of pathologic response on survival in pancreatic adenocarcinoma is not well established. Methods Data on 135 consecutive patients treated with chemoradiatio...

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Bibliographic Details
Published in:Annals of surgical oncology 2011-12, Vol.18 (13), p.3601-3607
Main Authors: Chun, Yun Shin, Cooper, Harry S., Cohen, Steven J., Konski, Andre, Burtness, Barbara, Denlinger, Crystal S., Astsaturov, Igor, Hall, Michael J., Hoffman, John P.
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - therapy
Neoplasm Staging
Oncology
Pancreatectomy
Pancreatic cancer
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - therapy
Pancreatic Tumors
Prognosis
Radiotherapy Dosage
Surgery
Surgical Oncology
Survival Rate
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Summary:Background Pathologic response to preoperative therapy is increasingly recognized as an important prognostic factor in solid tumors. The impact of pathologic response on survival in pancreatic adenocarcinoma is not well established. Methods Data on 135 consecutive patients treated with chemoradiation followed by pancreatectomy for adenocarcinoma of the pancreatic head and/or body between July 1987 and May 2009 were reviewed. Histopathologic examination was performed in 107 patients to determine pathologic response, defined as minor (
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-011-2086-4