High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model

We performed in vivo THz transmission imaging study on a subcutaneous xenograft mouse model for early human breast cancer detection. With a THz-fiber-scanning transmission imaging system, we continuously monitored the growth of human breast cancer in mice. Our in vivo study not only indicates that T...

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Bibliographic Details
Published in:Optics express 2011-10, Vol.19 (22), p.21552-21562
Main Authors: Chen, Hua, Chen, Te-Hsuen, Tseng, Tzu-Fang, Lu, Jen-Tang, Kuo, Chung-Chiu, Fu, Shih-Chen, Lee, Wen-Jeng, Tsai, Yuan-Fu, Huang, Yi-You, Chuang, Eric Y, Hwang, Yuh-Jing, Sun, Chi-Kuang
Format: Article
Language:English
Subjects:
Absorption
Animals
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Diagnostic Imaging - methods
Early Detection of Cancer - methods
Female
Humans
Magnetic Resonance Imaging
Mice
Mice, Inbred BALB C
Spectrum Analysis
Subcutaneous Tissue - pathology
Xenograft Model Antitumor Assays
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Summary:We performed in vivo THz transmission imaging study on a subcutaneous xenograft mouse model for early human breast cancer detection. With a THz-fiber-scanning transmission imaging system, we continuously monitored the growth of human breast cancer in mice. Our in vivo study not only indicates that THz transmission imaging can distinguish cancer from the surrounding fatty tissue, but also with a high sensitivity. Our in vivo study on the subcutaneous xenograft mouse model will encourage broad and further investigations for future early cancer screening by using THz imaging system.
ISSN:1094-4087
1094-4087
DOI:10.1364/oe.19.021552