Taurine suppresses oxidative stress-potentiated expression of lectin-like oxidized low-density lipoprotein receptor and restenosis in balloon-injured rabbit iliac artery

Summary 1. In endothelial cells, the major receptor for the binding and internalization of oxidized low‐density lipoprotein (LDL) is the lectin‐like oxidized LDL receptor (LOX‐1). The aim of the present study was to investigate the effects of taurine on intimal thickening and LOX‐1 expression under...

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Published in:Clinical and experimental pharmacology & physiology 2011-12, Vol.38 (12), p.811-818
Main Authors: Gokce, G, Ozsarlak-Sozer, G, Oran, I, Oktay, G, Ozkal, S, Kerry, Z
Format: Article
Language:English
Subjects:
Animals
Antioxidants - analysis
Atherosclerosis - chemically induced
Atherosclerosis - prevention & control
balloon injury
Buthionine Sulfoximine - pharmacology
Enzyme Inhibitors - pharmacology
glutathione
Iliac Artery - injuries
lectin-like oxidized low-density lipoprotein receptor (LOX-1)
Male
Oxidative Stress - physiology
Rabbits
restenosis
Scavenger Receptors, Class E - biosynthesis
taurine
Taurine - pharmacology
Tunica Intima - drug effects
Tunica Intima - metabolism
Tunica Media - drug effects
Tunica Media - metabolism
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Summary:Summary 1. In endothelial cells, the major receptor for the binding and internalization of oxidized low‐density lipoprotein (LDL) is the lectin‐like oxidized LDL receptor (LOX‐1). The aim of the present study was to investigate the effects of taurine on intimal thickening and LOX‐1 expression under normal and oxidative conditions. 2. The iliac artery of rabbits were subjected to balloon injury and oxidative stress was induced by 14 days treatment of rabbits with 75 mg/kg, s.c., buthionine sulfoximine (BSO), a specific inhibitor of glutathione synthesis. Taurine was administered in drinking water (1%, w/v) for 14 days in the presence (BSO + Taurine group) and in the absence of BSO treatment (Taurine group). In taurine and placebo groups, rabbits were injected with 4 mL, s.c., 0.9% NaCl (vehicle for BSO) for 14 days. 3. Taurine (1% in drinking water, w/v) preserved plasma levels of anti‐oxidants and lowered the increased blood pressure induced by BSO. The stenosis rate of 29.92% in the placebo group increased to 72.20% in the BSO group, which was significantly reduced to 42.21% by taurine (P 
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.2011.05612.x