Analysis of perinatal outcome by combination of first trimester maternal plasma homocysteine with uterine artery Doppler velocimetry

Objective To analyse the pregnancy outcome by combining plasma homocysteine with uterine artery Doppler velocimetry at 11 to 14 weeks of gestation. Method A prospective cohort study with 103 healthy pregnant women. Uterine artery Doppler velocimetry was performed at between 11 and 14 weeks of gestat...

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Bibliographic Details
Published in:Prenatal diagnosis 2011-12, Vol.31 (13), p.1246-1250
Main Authors: Kaymaz, Cemil, Demir, Ahmet, Bige, Ozgur, Cagliyan, Erkan, Cımrın, Dilek, Demir, Namik
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
Blood Flow Velocity
Delivery. Postpartum. Lactation
Female
Fetal Growth Retardation - blood
Fetal Growth Retardation - diagnostic imaging
first trimester
Folic Acid - blood
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Gestational Age
Gynecology. Andrology. Obstetrics
homocysteine
Homocysteine - blood
Humans
Hypertension, Pregnancy-Induced - blood
Hypertension, Pregnancy-Induced - diagnostic imaging
Medical sciences
Molecular and cellular biology
Pre-Eclampsia - blood
Pre-Eclampsia - diagnostic imaging
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - diagnostic imaging
Pregnancy Trimester, First - blood
Premature Birth - blood
Prognosis
Prospective Studies
Rheology
Ultrasonography, Prenatal
Uterine Artery - diagnostic imaging
uterine artery Doppler
Vitamin B 12 - blood
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Summary:Objective To analyse the pregnancy outcome by combining plasma homocysteine with uterine artery Doppler velocimetry at 11 to 14 weeks of gestation. Method A prospective cohort study with 103 healthy pregnant women. Uterine artery Doppler velocimetry was performed at between 11 and 14 weeks of gestation. Abnormal blood flow was defined as average pulsatility index >1.5 and presence of unilateral or bilateral diastolic notch. Doppler scores were calculated by a modified scoring method of uterine artery flow velocity waveforms. Serum for measurement of homocysteine, vitamin B12 and folate levels were collected when the ultrasonographic measurement was performed. Results Pre‐eclampsia developed in five, gestational hypertension in three, intrauterine growth restriction in two and preterm birth in eight patients. There was a significant difference between mean plasma homocysteine levels at different Doppler scores (p
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.2874