Serum Amyloid a Low-Density Lipoprotein Levels and Smoking Status in Obese Japanese Patients

• Published in: Journal of international medical research 2011-10, Vol.39 (5), p.1917-1922
• Main Authors: Kotani, K, Satoh-Asahara, N, Kato, Y, Araki, R, Himeno, A, Yamakage, H, Koyama, K, Tanabe, M, Oishi, M, Okajima, T, Shimatsu, A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers - blood; Blood Glucose; Blood Pressure; C-Reactive Protein - metabolism; Cholesterol - blood; Cross-Sectional Studies; Female; Humans; Japan; Lipoproteins, LDL - blood; Male; Middle Aged; Obesity - blood; Oxidation-Reduction; Serum Amyloid A Protein - analogs & derivatives; Smoking - blood; Surveys and Questionnaires
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/147323001103900536

Serum amyloid A low-density lipoprotein (SAA-LDL) is formed by an oxidative interaction and is considered to be a new marker related to oxidative modification of LDL. As the effect of smoking on oxidized LDL is of concern, this study investigated the association between SAA-LDL and smoking status. A total of 578 Japanese obese outpatients (mean ± SD age 50.5 ± 14.3 years) were studied. Smoking status was examined via a self-reported questionnaire. Cardiometabolic variables, including high-sensitivity C-reactive protein (hsCRP), were analysed in addition to SAA-LDL. There was an increasing trend in SAA-LDL levels from non- to ex- to current smokers, and significantly higher SAA-LDL levels were observed in current smokers versus non-smokers (median SAA-LDL level 36 μg/ml versus 28 μg/ml, respectively). This significant difference was reduced after adjusting for multiple confounders, including lipid levels. Smoking may be associated with increased levels of SAA-LDL in an obese Japanese population, but further studies are needed.