RAGE: a single receptor fits multiple ligands

The receptor for advanced glycation end products (RAGE) is a central signaling molecule in the innate immune system and is involved in the onset and sustainment of the inflammatory response. RAGE belongs to a class of pattern recognition receptors that recognize common features rather than a specifi...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2011-12, Vol.36 (12), p.625-632
Main Author: Fritz, Günter
Format: Article
Language:English
Subjects:
advanced glycation end products
Animals
electrostatic interactions
Humans
inflammation
innate immunity
Ligands
Models, Molecular
nuclear magnetic resonance spectroscopy
Receptor for Advanced Glycation End Products
receptors
Receptors, Immunologic - chemistry
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
Signal Transduction - immunology
X-ray diffraction
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Summary:The receptor for advanced glycation end products (RAGE) is a central signaling molecule in the innate immune system and is involved in the onset and sustainment of the inflammatory response. RAGE belongs to a class of pattern recognition receptors that recognize common features rather than a specific ligand. Recent structural information on the extracellular portion (ectodomain) of RAGE shed new light on this unusual ability. X-ray crystallographic, NMR and biochemical data suggest that ligand binding is driven largely by electrostatic interactions between the positively charged surface of the ectodomain and negatively charged ligands. In this article, I propose a putative mechanism of RAGE ligand recognition of receptor activation.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2011.08.008