Ditopic Ion Transport Systems: Anion-π Interactions and Halogen Bonds at Work

Single‐atom exchange series are introduced to extract the individual contributions of halogen bonds and anion–π interactions to the transport of anions across lipid bilayer membranes (see picture). Known cation binding sites are used for counterion activation of the neutral calix[4]arene transporter...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-12, Vol.50 (49), p.11675-11678
Main Authors: Vargas Jentzsch, Andreas, Emery, Daniel, Mareda, Jiri, Metrangolo, Pierangelo, Resnati, Giuseppe, Matile, Stefan
Format: Article
Language:English
Subjects:
anion transport
anion-π interactions
anions
Anions - chemistry
Anions - metabolism
Binding Sites
Calixarenes - chemistry
Calixarenes - metabolism
halogen bonds
Ion Transport
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Models, Molecular
Phenols - chemistry
Phenols - metabolism
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Summary:Single‐atom exchange series are introduced to extract the individual contributions of halogen bonds and anion–π interactions to the transport of anions across lipid bilayer membranes (see picture). Known cation binding sites are used for counterion activation of the neutral calix[4]arene transporters. The experimental evidence for anion transport with halogen bonds is unprecedented.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201104966