Renal Function After Catheter Ablation of Atrial Fibrillation

Kidney function is a known predictor of cardiovascular morbidity and mortality. Although patients with atrial fibrillation (AF) often have kidney dysfunction, less is known about the association between AF and kidney function. We sought to assess changes in kidney function after catheter ablation of...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2011-11, Vol.124 (22), p.2380-2387
Main Authors: TAKAHASHI, Yoshihide, TAKAHASHI, Atsushi, ISOBE, Mitsuaki, KUWAHARA, Taishi, OKUBO, Kenji, FUJINO, Tadashi, TAKAGI, Katsumasa, NAKASHIMA, Emiko, KAMIISHI, Tetsuo, HIKITA, Hiroyuki, HIRAO, Kenzo
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - complications
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Catheter Ablation
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
Glomerular Filtration Rate - physiology
Glomerulonephritis
Humans
Kidney - physiopathology
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Prospective Studies
Renal Insufficiency - epidemiology
Risk Factors
Sinoatrial Node - physiopathology
Treatment Outcome
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Summary:Kidney function is a known predictor of cardiovascular morbidity and mortality. Although patients with atrial fibrillation (AF) often have kidney dysfunction, less is known about the association between AF and kidney function. We sought to assess changes in kidney function after catheter ablation of AF. Patients who underwent catheter ablation of AF were recruited for the present prospective study. Estimated glomerular filtration rate (eGFR) was evaluated before and 1 year after the ablation. Three hundred eighty-six patients (paroxysmal AF, 135; persistent AF, 106; longstanding persistent AF, 145) were studied. Their baseline eGFR was 68 ± 14 mL · min(-1) · 1.73 m(-2). Sixty-six percent and 26% of patients had eGFR of 60 to 89 and 30 to 59 mL · min(-1) · 1.73 m(-2), respectively. Overall, 278 patients (72%) were arrhythmia free over a 1-year follow-up. In patients free from arrhythmia, eGFR increased 3 months later and was maintained until 1 year, whereas in patients with recurrences, eGFR had decreased over 1 year. Changes in eGFR over 1 year in patients free from arrhythmia differed significantly compared with those with recurrences (3 ± 8 versus -2 ± 8 mL · min(-1) · 1.73 m(-2); P
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.111.047266