Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development

Quantitative and systems pharmacology (QSP) is an emerging modelling technique that combines the flexibility of systems biology and tractability of compartmental pharmacokinetic–pharmacodynamic modelling techniques. Historically, there has been extensive use of QSP within the field of pharmacokineti...

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Bibliographic Details
Published in:Drug discovery today 2011-12, Vol.16 (23), p.1031-1036
Main Authors: Agoram, Balaji M., Demin, Oleg
Format: Article
Language:English
Subjects:
Animals
Drug Design
Drug Discovery - methods
Humans
Models, Biological
Pharmacology - methods
Systems Biology - methods
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Summary:Quantitative and systems pharmacology (QSP) is an emerging modelling technique that combines the flexibility of systems biology and tractability of compartmental pharmacokinetic–pharmacodynamic modelling techniques. Historically, there has been extensive use of QSP within the field of pharmacokinetics to optimise drug biopharmaceutical properties. However, application to target and biomarker selection, and design of preclinical and clinical studies is limited, but growing rapidly. In this article we highlight the impact of QSP within drug discovery and development by citing examples from within the field of pharmacology and we argue for a more systematic integration of QSP within the drug discovery and development paradigm.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2011.10.001