Synthesis of 1,2,3-triazole-fused heterocycles via Pd-catalyzed cyclization of 5-iodotriazoles

A convenient approach toward polycyclic frameworks containing fused 1,2,3-triazoles is described. The synthesis consists of a Cu-catalyzed cycloaddition and an intramolecular Pd-catalyzed direct arylation or Heck reaction, and affords the products in good to excellent yields.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (1), p.55-57
Main Authors: Schulman, Jacqueline M, Friedman, Adam A, Panteleev, Jane, Lautens, Mark
Format: Article
Language:English
Subjects:
Catalysis
Chemistry Techniques, Synthetic - methods
Copper
Cyclization
Cycloaddition
Halogenation
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Palladium
Palladium - chemistry
Synthesis
Triazoles - chemistry
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Description
Summary:A convenient approach toward polycyclic frameworks containing fused 1,2,3-triazoles is described. The synthesis consists of a Cu-catalyzed cycloaddition and an intramolecular Pd-catalyzed direct arylation or Heck reaction, and affords the products in good to excellent yields.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16110e