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Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease
Background While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice. Objective To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using h...
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| Published in: | Pediatric radiology 2011-12, Vol.41 (12), p.1552-1558 |
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| cites | cdi_FETCH-LOGICAL-c371t-34db29e35da14557866f2758813c599d91b2488e79299f0e24ec662664107e0b3 |
| container_end_page | 1558 |
| container_issue | 12 |
| container_start_page | 1552 |
| container_title | Pediatric radiology |
| container_volume | 41 |
| creator | Dillman, Jonathan R. Ladino-Torres, Maria F. Adler, Jeremy DeMatos-Malliard, Vera McHugh, Jonathan B. Khalatbari, Shokoufeh Strouse, Peter J. |
| description | Background
While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice.
Objective
To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using histopathology as the reference standard.
Materials and methods
Pediatric MRE examinations performed between April 2009 and December 2010 were identified. Subjects were excluded if they did not have Crohn disease, if they had Crohn disease but no correlative histopathology within 2 months of imaging, or if they had undergone prior bowel resection. Pertinent MRE and histopathology reports were reviewed, and normal and abnormal bowel segments were documented.
Results
Thirty-two pediatric MRE examinations were identified with correlative histopathology. MRE had an overall sensitivity of 94% for detecting the presence of Crohn disease, in general. At the bowel segmental level, MRE had a sensitivity of 66%, specificity of 90%, positive predictive value of 85% and negative predictive value of 76%. The terminal ileum was abnormal by MRE in 11 of 15 (73%) subjects lacking a diagnostic biopsy of this bowel segment.
Conclusion
MRE successfully identifies small bowel and colon segments affected by pediatric Crohn disease. |
| doi_str_mv | 10.1007/s00247-011-2186-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_907146434</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>907146434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-34db29e35da14557866f2758813c599d91b2488e79299f0e24ec662664107e0b3</originalsourceid><addsrcrecordid>eNp1kE2L1EAQhhtR3NnVH-BFGjx4ilb1R7r7KMOqCyuC6FGanqQy6SWTjt2JMP_eLFlFBE91qOd9q3gYe4HwBgHM2wIglKkAsRJo6woesR0qKSp0zj5mO5CAFSjlLthlKXcAIDXKp-xCoLHaarFj3_fpNIUcSxp56vinL5zGmXI65jD1Zx7GlvexzGkKc5-GdDzzOPK5J04_w7CEOW65idoY5hwbvs-pH3kbC4VCz9iTLgyFnj_MK_bt_fXX_cfq9vOHm_2726qRBudKqvYgHEndBlRaG1vXnTDaWpSNdq51eBDKWjJOONcBCUVNXYu6VgiG4CCv2Outd8rpx0Jl9qdYGhqGMFJaindgUNVKqpV89Q95l5Y8rs95BKe1AIv1SuFGNTmVkqnzU46nkM8r5O_V-029X9X7e_Ue1szLh-blcKL2T-K36xUQG1DW1Xik_Pfp_7X-AnS2jPM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1095520816</pqid></control><display><type>article</type><title>Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease</title><source>Springer Nature</source><creator>Dillman, Jonathan R. ; Ladino-Torres, Maria F. ; Adler, Jeremy ; DeMatos-Malliard, Vera ; McHugh, Jonathan B. ; Khalatbari, Shokoufeh ; Strouse, Peter J.</creator><creatorcontrib>Dillman, Jonathan R. ; Ladino-Torres, Maria F. ; Adler, Jeremy ; DeMatos-Malliard, Vera ; McHugh, Jonathan B. ; Khalatbari, Shokoufeh ; Strouse, Peter J.</creatorcontrib><description>Background
While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice.
Objective
To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using histopathology as the reference standard.
Materials and methods
Pediatric MRE examinations performed between April 2009 and December 2010 were identified. Subjects were excluded if they did not have Crohn disease, if they had Crohn disease but no correlative histopathology within 2 months of imaging, or if they had undergone prior bowel resection. Pertinent MRE and histopathology reports were reviewed, and normal and abnormal bowel segments were documented.
Results
Thirty-two pediatric MRE examinations were identified with correlative histopathology. MRE had an overall sensitivity of 94% for detecting the presence of Crohn disease, in general. At the bowel segmental level, MRE had a sensitivity of 66%, specificity of 90%, positive predictive value of 85% and negative predictive value of 76%. The terminal ileum was abnormal by MRE in 11 of 15 (73%) subjects lacking a diagnostic biopsy of this bowel segment.
Conclusion
MRE successfully identifies small bowel and colon segments affected by pediatric Crohn disease.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-011-2186-0</identifier><identifier>PMID: 21785852</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Child ; Colon - pathology ; Crohn Disease - pathology ; Female ; Humans ; Imaging ; Intestine, Small - pathology ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Neuroradiology ; Nuclear Medicine ; Oncology ; Original Article ; Pediatrics ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasound</subject><ispartof>Pediatric radiology, 2011-12, Vol.41 (12), p.1552-1558</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-34db29e35da14557866f2758813c599d91b2488e79299f0e24ec662664107e0b3</citedby><cites>FETCH-LOGICAL-c371t-34db29e35da14557866f2758813c599d91b2488e79299f0e24ec662664107e0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21785852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dillman, Jonathan R.</creatorcontrib><creatorcontrib>Ladino-Torres, Maria F.</creatorcontrib><creatorcontrib>Adler, Jeremy</creatorcontrib><creatorcontrib>DeMatos-Malliard, Vera</creatorcontrib><creatorcontrib>McHugh, Jonathan B.</creatorcontrib><creatorcontrib>Khalatbari, Shokoufeh</creatorcontrib><creatorcontrib>Strouse, Peter J.</creatorcontrib><title>Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Background
While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice.
Objective
To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using histopathology as the reference standard.
Materials and methods
Pediatric MRE examinations performed between April 2009 and December 2010 were identified. Subjects were excluded if they did not have Crohn disease, if they had Crohn disease but no correlative histopathology within 2 months of imaging, or if they had undergone prior bowel resection. Pertinent MRE and histopathology reports were reviewed, and normal and abnormal bowel segments were documented.
Results
Thirty-two pediatric MRE examinations were identified with correlative histopathology. MRE had an overall sensitivity of 94% for detecting the presence of Crohn disease, in general. At the bowel segmental level, MRE had a sensitivity of 66%, specificity of 90%, positive predictive value of 85% and negative predictive value of 76%. The terminal ileum was abnormal by MRE in 11 of 15 (73%) subjects lacking a diagnostic biopsy of this bowel segment.
Conclusion
MRE successfully identifies small bowel and colon segments affected by pediatric Crohn disease.</description><subject>Adolescent</subject><subject>Child</subject><subject>Colon - pathology</subject><subject>Crohn Disease - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Intestine, Small - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasound</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kE2L1EAQhhtR3NnVH-BFGjx4ilb1R7r7KMOqCyuC6FGanqQy6SWTjt2JMP_eLFlFBE91qOd9q3gYe4HwBgHM2wIglKkAsRJo6woesR0qKSp0zj5mO5CAFSjlLthlKXcAIDXKp-xCoLHaarFj3_fpNIUcSxp56vinL5zGmXI65jD1Zx7GlvexzGkKc5-GdDzzOPK5J04_w7CEOW65idoY5hwbvs-pH3kbC4VCz9iTLgyFnj_MK_bt_fXX_cfq9vOHm_2726qRBudKqvYgHEndBlRaG1vXnTDaWpSNdq51eBDKWjJOONcBCUVNXYu6VgiG4CCv2Outd8rpx0Jl9qdYGhqGMFJaindgUNVKqpV89Q95l5Y8rs95BKe1AIv1SuFGNTmVkqnzU46nkM8r5O_V-029X9X7e_Ue1szLh-blcKL2T-K36xUQG1DW1Xik_Pfp_7X-AnS2jPM</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Dillman, Jonathan R.</creator><creator>Ladino-Torres, Maria F.</creator><creator>Adler, Jeremy</creator><creator>DeMatos-Malliard, Vera</creator><creator>McHugh, Jonathan B.</creator><creator>Khalatbari, Shokoufeh</creator><creator>Strouse, Peter J.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease</title><author>Dillman, Jonathan R. ; Ladino-Torres, Maria F. ; Adler, Jeremy ; DeMatos-Malliard, Vera ; McHugh, Jonathan B. ; Khalatbari, Shokoufeh ; Strouse, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-34db29e35da14557866f2758813c599d91b2488e79299f0e24ec662664107e0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Colon - pathology</topic><topic>Crohn Disease - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Intestine, Small - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dillman, Jonathan R.</creatorcontrib><creatorcontrib>Ladino-Torres, Maria F.</creatorcontrib><creatorcontrib>Adler, Jeremy</creatorcontrib><creatorcontrib>DeMatos-Malliard, Vera</creatorcontrib><creatorcontrib>McHugh, Jonathan B.</creatorcontrib><creatorcontrib>Khalatbari, Shokoufeh</creatorcontrib><creatorcontrib>Strouse, Peter J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dillman, Jonathan R.</au><au>Ladino-Torres, Maria F.</au><au>Adler, Jeremy</au><au>DeMatos-Malliard, Vera</au><au>McHugh, Jonathan B.</au><au>Khalatbari, Shokoufeh</au><au>Strouse, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease</atitle><jtitle>Pediatric radiology</jtitle><stitle>Pediatr Radiol</stitle><addtitle>Pediatr Radiol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>41</volume><issue>12</issue><spage>1552</spage><epage>1558</epage><pages>1552-1558</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Background
While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice.
Objective
To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using histopathology as the reference standard.
Materials and methods
Pediatric MRE examinations performed between April 2009 and December 2010 were identified. Subjects were excluded if they did not have Crohn disease, if they had Crohn disease but no correlative histopathology within 2 months of imaging, or if they had undergone prior bowel resection. Pertinent MRE and histopathology reports were reviewed, and normal and abnormal bowel segments were documented.
Results
Thirty-two pediatric MRE examinations were identified with correlative histopathology. MRE had an overall sensitivity of 94% for detecting the presence of Crohn disease, in general. At the bowel segmental level, MRE had a sensitivity of 66%, specificity of 90%, positive predictive value of 85% and negative predictive value of 76%. The terminal ileum was abnormal by MRE in 11 of 15 (73%) subjects lacking a diagnostic biopsy of this bowel segment.
Conclusion
MRE successfully identifies small bowel and colon segments affected by pediatric Crohn disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21785852</pmid><doi>10.1007/s00247-011-2186-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-0449 |
| ispartof | Pediatric radiology, 2011-12, Vol.41 (12), p.1552-1558 |
| issn | 0301-0449 1432-1998 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_907146434 |
| source | Springer Nature |
| subjects | Adolescent Child Colon - pathology Crohn Disease - pathology Female Humans Imaging Intestine, Small - pathology Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Neuroradiology Nuclear Medicine Oncology Original Article Pediatrics Radiology Reproducibility of Results Sensitivity and Specificity Ultrasound |
| title | Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease |
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