Associations of Retinal Microvascular Signs and Intracranial Large Artery Disease

Intracranial large artery disease (ICLAD) is a major cause of ischemic stroke. Retinal microvascular changes are associated with stroke, including small vessel cerebral disease and extracranial carotid disease. We examined the relationship between ICLAD and retinal microvascular changes. This is a p...

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Published in:Stroke (1970) 2011-03, Vol.42 (3), p.812-814
Main Authors: DE SILVA, Deidre A, MANZANO, Jennifer J. F, LINDLEY, Richard I, WONG, Tien-Yin, WONG, Meng-Cheong, WOON, Fung-Peng, LIU, Erica Yang, LEE, Moi-Pin, GAN, Hui-Yee, CHEN, Christopher P. L. H, CHANG, Hui-Meng, MITCHELL, Paul, JIE JIN WANG
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cerebrovascular Circulation - physiology
Cohort Studies
Female
Humans
Intracranial Arterial Diseases - complications
Intracranial Arterial Diseases - diagnosis
Intracranial Arterial Diseases - physiopathology
Male
Medical sciences
Microvessels - physiopathology
Middle Aged
Neurology
Prospective Studies
Retinal Diseases - complications
Retinal Diseases - diagnosis
Retinal Diseases - physiopathology
Retinal Vessels - physiopathology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Vascular diseases and vascular malformations of the nervous system
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Summary:Intracranial large artery disease (ICLAD) is a major cause of ischemic stroke. Retinal microvascular changes are associated with stroke, including small vessel cerebral disease and extracranial carotid disease. We examined the relationship between ICLAD and retinal microvascular changes. This is a prospective cohort of 802 acute ischemic stroke patients. Retinal changes were assessed from photographs by graders masked to clinical data. ICLAD was evaluated using prespecified criteria. ICLAD was not associated with ipsilateral retinal arteriolar/venular caliber, focal arteriolar narrowing, or arteriovenous nicking. Severe enhanced arteriolar light reflex was independently associated with any ICLAD (P=0.006) and severe ICLAD (P
ISSN:0039-2499
1524-4628
1524-4628
DOI:10.1161/STROKEAHA.110.589960