Role of HIV-1 DNA levels as clinical marker of HIV-1-associated nephropathies

HIV-associated nephropathy (HIVAN) is usually diagnosed in virologically uncontrolled infected patients. However, HIVAN can occur in some cases with undetectable HIV-1 RNA levels. We suggested that intracellular HIV-1 proviral DNA load can be used as a marker in this particular patient population. R...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2011-02, Vol.26 (2), p.580-583
Main Authors: IZZEDINE, Hassane, ACHARYA, Veena, WIRDEN, Marc, CLUZEL, Philippe, SENE, Damien, LUCAS, Gregory M, BAUMELOU, Alain, ATTA, Mohamed G
Format: Article
Language:English
Subjects:
Adult
AIDS-Associated Nephropathy - diagnosis
AIDS-Associated Nephropathy - virology
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Associated diseases and complications
Biological and medical sciences
Biomarkers - analysis
Biopsy
CD4 antigen
Cell number
Diabetes. Impaired glucose tolerance
DNA
DNA, Viral - analysis
Emergency and intensive care: renal failure. Dialysis management
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
HIV-1 - isolation & purification
Human immunodeficiency virus 1
Humans
Intensive care medicine
Kidney
Kidney - pathology
Kidney - virology
Leukocytes, Mononuclear - virology
Male
Medical sciences
Middle Aged
Nephropathy
Peripheral blood mononuclear cells
Prospective Studies
Proviruses
RNA
Viral Load
Viremia
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Summary:HIV-associated nephropathy (HIVAN) is usually diagnosed in virologically uncontrolled infected patients. However, HIVAN can occur in some cases with undetectable HIV-1 RNA levels. We suggested that intracellular HIV-1 proviral DNA load can be used as a marker in this particular patient population. Renal tissue HIV-1 proviral DNA, peripheral blood mononuclear cells (PBMCs) HIV-1 proviral DNA, plasma HIV-1 RNA and peripheral blood CD4-positive lymphocyte counts were quantified and assessed in 100 HIV-1-infected individuals (49 with undetectable HIV-1 RNA level viraemia) who underwent a kidney biopsy for renal abnormalities in a prospective study. A proviral DNA load was detected in patients with HIV-1-associated nephropathy with a negative plasma viral RNA load. None of the patients with a proviral DNA load of
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfq414