Application of Alpha7 Nicotinic Acetylcholine Receptor Agonists in Inflammatory Diseases: An Overview

Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that pro...

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Bibliographic Details
Published in:Pharmaceutical research 2011-02, Vol.28 (2), p.413-416
Main Authors: Marrero, Mario B, Bencherif, Merouane, Lippiello, Patrick M, Lucas, Rudolf
Format: Article
Language:English
Subjects:
alpha7 Nicotinic Acetylcholine Receptor
alpha7 nicotinic acetylcholine receptor agonists
Animals
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
cholinergic anti-inflammatory pathway
Commentary
Cytokines
Cytokines - immunology
Endothelial Cells - drug effects
Humans
Immunology
inflammation
Inflammation - physiopathology
Inflammation - prevention & control
Inflammatory diseases
Interleukins - metabolism
Jak/STAT pathway
Macrophages - metabolism
Medical Law
Mice
Neurotransmitters
Nicotinic Agonists - chemistry
Nicotinic Agonists - pharmacology
Nicotinic Agonists - therapeutic use
Pharmacology
Pharmacology/Toxicology
Pharmacy
Receptors, Nicotinic - metabolism
Signal Transduction - drug effects
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as atherosclerosis, Crohn's, Alzheimer's and diabetes. Numerous cytokines play a significant role in this process, though tumor necrosis factor (TNF) and various interleukins are thought to be among the most important regulators. These proinflammatory cytokines promote the above-described diseases by inducing endothelial cell dysfunction. In this brief commentary we will discuss some of the latest advances and discoveries in the treatment of these inflammatory diseases, making use of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists.
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-010-0283-7