Perirhinal Cortex Supports Encoding and Familiarity-Based Recognition of Novel Associations

Results from imaging and lesion studies of item recognition memory have suggested that the hippocampus supports memory for the arbitrary associations that form the basis of episodic recollection, whereas the perirhinal cortex (PRc) supports familiarity for individual items. This view has been challe...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2008-08, Vol.59 (4), p.554-560
Main Authors: Haskins, A. Logan, Yonelinas, Andrew P., Quamme, Joel R., Ranganath, Charan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Amnesia
Association Learning - physiology
Brain Mapping
Evoked Potentials - physiology
Female
Hippocampus - physiology
Humans
Hypotheses
Magnetic Resonance Imaging
Male
Mental Recall - physiology
Recognition (Psychology) - physiology
Reference Values
ROC Curve
SYSNEURO
Temporal Lobe - physiology
Verbal Learning - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Results from imaging and lesion studies of item recognition memory have suggested that the hippocampus supports memory for the arbitrary associations that form the basis of episodic recollection, whereas the perirhinal cortex (PRc) supports familiarity for individual items. This view has been challenged, however, by findings showing that PRc may contribute to associative recognition, a task thought to measure relational or recollective memory. Here, using functional magnetic resonance imaging, we demonstrate that PRc activity is increased when pairs of items are processed as a single configuration or unit and that this activity predicts subsequent familiarity-based associative memory. These results explain the discrepancy in the literature by showing that novel associations can be encoded in a unitized manner, thereby allowing PRc to support associative recognition based on familiarity.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2008.07.035