Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 M and also show...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2011-03, Vol.21 (6), p.1716-1718
Main Authors: Cho, Jun-Young, Kwon, Yun-Ju, Sohn, Mi-Jin, Seok, Soon-Ja, Kim, Won-Gon
Format: Article
Language:English
Subjects:
Antibacterial
antibacterial properties
Biological and medical sciences
Catechols - pharmacology
chemistry
culture media
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
Enoyl-ACP reductase
Enzyme Inhibitors - pharmacology
Fungi - enzymology
General pharmacology
Hispidin
Inhibitor
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Medical sciences
medicinal fungi
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phellinus linteus
Pyrones - pharmacology
spectral analysis
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Staphylococcus aureus
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Summary:A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 M and also showed antibacterial activity against S. aureus and MRSA. A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 μM and also showed antibacterial activity against S. aureus and MRSA.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.01.080