Haplotype-Based Case-Control Study of the Human CYP11B2 Gene and Essential Hypertension in Yi and Hani Minorities of China

This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the...

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Bibliographic Details
Published in:Biochemical genetics 2011-02, Vol.49 (1-2), p.122-137
Main Authors: Chen, Bifeng, Nie, Shengjie, Yue, Zhaoping, Shou, Weihua, Xiao, Chunjie
Format: Article
Language:English
Subjects:
Alleles
Asian Continental Ancestry Group - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Case studies
Case-Control Studies
China
CYP11B2 gene
Cytochrome P-450 CYP11B2 - genetics
Cytochrome P-450 CYP11B2 - metabolism
Essential hypertension
Female
Gene Frequency
Genetic Predisposition to Disease - ethnology
Genotype
Haplotype
Haplotypes - genetics
Human Genetics
Humans
Hypertension
Hypertension - ethnology
Hypertension - etiology
Hypertension - genetics
Hypertension - physiopathology
Male
Medical Microbiology
Middle Aged
Minority Groups
Polymorphism, Genetic
Polymorphism, Single Nucleotide
single nucleotide polymorphism
Tag SNP
Zoology
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Summary:This haplotype-based case-control study investigated whether the aldosterone synthase gene (CYP11B2) might be implicated in the pathogenesis of essential hypertension in Yi (226 individuals) and Hani (296 individuals) minorities of China. Four tag SNPs (rs4536, rs4545, rs3097, and rs3802230) and the K173R polymorphism were genotyped using the PCR-RFLP method. In the Hani minority, rs4536 was significantly associated with hypertension, after Bonferroni correction. H9 AGGC constructed by tag SNPs was significantly higher in hypertensives than in controls (P = 0.001). Further, we observed that haplotype AGGC remained significantly associated with male hypertension after adjustment for covariates (OR = 3.76, P = 0.002). In the Yi minority, it was found that the CYP11B2 gene was not significantly associated with hypertension. These results indicated that haplotype AGGC conferred an increased risk for hypertension in the Hani minority male. In addition, CYP11B2 may not be associated with hypertension in the Yi minority of China.
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-010-9393-5