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Organophosphate induced delayed polyneuropathy in man: An overview

Abstract About 80 years have passed since the first cases of organophosphate induced delayed polyneuropathy (OPIDP), as the consequence of human poisoning with certain organophosphorus compounds, were described in the literature. OPIDP is a relatively rare neurodegenerative disorder in humans charac...

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Published in:	Clinical neurology and neurosurgery 2011-01, Vol.113 (1), p.7-10
Main Authors:	JOKANOVIC, Milan, KOSANOVIC, Melita, BRKIC, Dejan, VUKOMANOVIC, Predrag
Format:	Article
Language:	English
Subjects:	Aging Animals Ataxia Biological and medical sciences Drug dosages Esterases - metabolism Humans Medical sciences Neurology Neurons Neuropathy target esterase Neurosurgery Neurotoxicity Syndromes - diagnosis Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - etiology Organophosphate induced delayed polyneuropathy Organophosphates - toxicity Organophosphorus Phosphorylation Poisoning Polyneuropathies - chemically induced Polyneuropathies - diagnosis Polyneuropathies - drug therapy Polyneuropathies - enzymology Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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description	Abstract About 80 years have passed since the first cases of organophosphate induced delayed polyneuropathy (OPIDP), as the consequence of human poisoning with certain organophosphorus compounds, were described in the literature. OPIDP is a relatively rare neurodegenerative disorder in humans characterized by loss of function, ataxia and paralysis of distal parts of sensory and motor axons in peripheral nerves and ascending and descending tracts of spinal cord appearing 2–3 weeks after exposure or later. The molecular target for OPIDP is considered to be an enzyme in the nervous system known as neuropathy target esterase (NTE). This review discusses OPIDP in man with emphasis on clinical presentation, pathogenesis, molecular mechanisms, and possibilities for prevention/therapy.
doi_str_mv	10.1016/j.clineuro.2010.08.015
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OPIDP is a relatively rare neurodegenerative disorder in humans characterized by loss of function, ataxia and paralysis of distal parts of sensory and motor axons in peripheral nerves and ascending and descending tracts of spinal cord appearing 2–3 weeks after exposure or later. The molecular target for OPIDP is considered to be an enzyme in the nervous system known as neuropathy target esterase (NTE). 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OPIDP is a relatively rare neurodegenerative disorder in humans characterized by loss of function, ataxia and paralysis of distal parts of sensory and motor axons in peripheral nerves and ascending and descending tracts of spinal cord appearing 2–3 weeks after exposure or later. The molecular target for OPIDP is considered to be an enzyme in the nervous system known as neuropathy target esterase (NTE). 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subjects	Aging Animals Ataxia Biological and medical sciences Drug dosages Esterases - metabolism Humans Medical sciences Neurology Neurons Neuropathy target esterase Neurosurgery Neurotoxicity Syndromes - diagnosis Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - etiology Organophosphate induced delayed polyneuropathy Organophosphates - toxicity Organophosphorus Phosphorylation Poisoning Polyneuropathies - chemically induced Polyneuropathies - diagnosis Polyneuropathies - drug therapy Polyneuropathies - enzymology Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
title	Organophosphate induced delayed polyneuropathy in man: An overview
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