Rickettsial infection with hemophagocytosis

A five-year-old girl admitted with scrub typhus developed multiple organ dysfunction associated with hyperferritinaemia, hypofibrinogenaemia and hyperlipidaemia. Bone marrow aspiration studies confirmed haemophagocytic lymphohistiocytosis (HLH). HLH is a syndrome characterized by the uncontrolled ac...

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Bibliographic Details
Published in:Tropical doctor 2011-04, Vol.41 (2), p.111-112
Main Authors: Jayakrishnan, M P, Veny, John, Feroze, M
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Bone Marrow - pathology
Child, Preschool
Diagnosis, Differential
Doxycycline - therapeutic use
Female
General aspects
Human bacterial diseases
Humans
Infectious diseases
Lymphohistiocytosis, Hemophagocytic - complications
Lymphohistiocytosis, Hemophagocytic - drug therapy
Lymphohistiocytosis, Hemophagocytic - pathology
Medical sciences
Multiple Organ Failure - virology
Pancytopenia - pathology
Prognosis
Rickettsia Infections - complications
Rickettsial diseases
Scrub Typhus - complications
Syndrome
T-Lymphocytes - pathology
T-Lymphocytes - virology
Treatment Outcome
Tropical bacterial diseases
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Summary:A five-year-old girl admitted with scrub typhus developed multiple organ dysfunction associated with hyperferritinaemia, hypofibrinogenaemia and hyperlipidaemia. Bone marrow aspiration studies confirmed haemophagocytic lymphohistiocytosis (HLH). HLH is a syndrome characterized by the uncontrolled activation and proliferation of macrophages and T-cells and can occur together with infections, connective tissue disorders, malignancies and genetic disorders.
ISSN:0049-4755
1758-1133
DOI:10.1258/td.2010.100303