Pyoderma Gangrenosumalike Lesions in Leukocyte Adhesion Deficiency I Treated with Intravenous Immunoglobulin

A 31-year-old Caucasian male with leukocyte adhesion deficiency I and a 20-year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic steroid...

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Bibliographic Details
Published in:Pediatric dermatology 2011-03, Vol.28 (2), p.156-161
Main Authors: Nord, Kristin M, Pappert, Amy S, Grossman, Marc E
Format: Article
Language:English
Subjects:
Antibiotics
Fatigue
Immunoglobulins
infliximab
Intravenous administration
Leg
Leukocytes
Monoclonal antibodies
Mycophenolate mofetil
Pain
Pyoderma
Steroid hormones
Tumor necrosis factor- alpha
Ulcers
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Summary:A 31-year-old Caucasian male with leukocyte adhesion deficiency I and a 20-year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic steroids, numerous courses of systemic antibiotics, and brief trials of infliximab and mycophenolate mofetil. He was treated with monthly intravenous immunoglobulin infusions. Upon completion of six courses of intravenous immunoglobulin his ulcerations had nearly healed for the first time in a decade.
ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2010.01123.x