PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie

In contrast to scrapie in sheep, the genetic basis of susceptibility to scrapie in goats is not well understood. To study the association of prion protein ( PrP) alleles with susceptibility to scrapie in goats in Cyprus, the coding sequence of the caprine PrP gene was determined in 717 goats, includ...

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Bibliographic Details
Published in:The veterinary journal (1997) 2011-02, Vol.187 (2), p.245-250
Main Authors: Papasavva-Stylianou, Penelope, Windl, Otto, Saunders, Ginny, Mavrikiou, Petroula, Toumazos, Pavlos, Kakoyiannis, Charalambos
Format: Article
Language:English
Subjects:
Alleles
Amino Acids - genetics
Animals
aspartic acid
Case-Control Studies
Codon - genetics
Cyprus
genetic polymorphism
Genetic Predisposition to Disease
Genotype
Goat Diseases - genetics
Goats
Goats - genetics
heterozygosity
homozygosity
Polymorphism, Genetic - genetics
Polymorphisms
prions
Prions - genetics
PrP gene
Scrapie
Scrapie - genetics
Sequence Analysis, DNA - veterinary
serine
sheep
stop codon
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Summary:In contrast to scrapie in sheep, the genetic basis of susceptibility to scrapie in goats is not well understood. To study the association of prion protein ( PrP) alleles with susceptibility to scrapie in goats in Cyprus, the coding sequence of the caprine PrP gene was determined in 717 goats, including 218 scrapie positive animals. Several novel polymorphisms were detected, such as a novel octarepeat variant and a stop codon mutation. Amino acids at codons 146 and 154 were associated with susceptibility to goat scrapie. Animals heterozygous for serine (S) and aspartate (D) at codon 146 were significantly under-represented in scrapie positive animals and no positive animals were found that were homozygous for these amino acids at codon 146. These results might provide the basis for genetic control of scrapie in Cypriot goats.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2009.10.015