Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of “self” and provoking overexuberant inflammatory processes. In this Review we discuss this b...

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Bibliographic Details
Published in:Cell 2010-03, Vol.140 (6), p.845-858
Main Authors: Littman, Dan R., Rudensky, Alexander Y.
Format: Article
Language:English
Subjects:
Bacteria - immunology
Immune Tolerance
Inflammation - immunology
Inflammation - pathology
Intestinal Mucosa - microbiology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of “self” and provoking overexuberant inflammatory processes. In this Review we discuss this balance achieved in large part by interactions of different classes of T lymphocytes that have potent pro- or anti-inflammatory activity in the context of genetic and environmental factors, particularly the commensal microbiota.
ISSN:0092-8674
0020-7683
1097-4172
DOI:10.1016/j.cell.2010.02.021