Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

Cancer is one of the most deadly diseases in the world. Although advances in the field of chemo-preventive and therapeutic medicine have been made regularly over the last ten years, the search for novel anticancer treatments continues. In this field, the marine environment, with its rich variety of...

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Bibliographic Details
Published in:Biotechnology advances 2011-09, Vol.29 (5), p.531-547
Main Authors: Schumacher, Marc, Kelkel, Mareike, Dicato, Mario, Diederich, Marc
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Antitumor activity
Apoptosis
Apoptosis - drug effects
Aquatic Organisms - chemistry
Biological and medical sciences
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Biotechnology
Cancer
Cancer prevention
Cell death
Cell Growth Processes - drug effects
Chemotherapy
Drug Discovery
Fundamental and applied biological sciences. Psychology
Gold
Humans
Invasion
Marine antitumor compounds
Marine environment
medicine
Metastases
Metastasis
Neoplasm Metastasis
Neovascularization, Pathologic - drug therapy
Proliferation
Replication
Telomerase
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Summary:Cancer is one of the most deadly diseases in the world. Although advances in the field of chemo-preventive and therapeutic medicine have been made regularly over the last ten years, the search for novel anticancer treatments continues. In this field, the marine environment, with its rich variety of organisms, is a largely untapped source of novel compounds with potent antitumor activity. Although many reviews of marine anticancer compounds have been published, we focus here on selected marine compounds that act on the six hallmarks of cancer presented namely self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replication, sustained angiogenesis and tissue invasion and metastasis.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2011.02.002