Cobalt oxide acicular nanorods with high sensitivity for the non-enzymatic detection of glucose

Acicular cobalt oxide nanorods (CoONRs) were prepared for the non-enzymatic detection of glucose, first by directly growing layered cobalt carbonate hydroxide (LCCH) on a conducting fluorine-doped tin oxide (FTO) substrate using a simple chemical bath deposition (CBD) technique and then by transform...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2011-09, Vol.27 (1), p.125-131
Main Authors: Kung, Chung-Wei, Lin, Chia-Yu, Lai, Yi-Hsuan, Vittal, R., Ho, Kuo-Chuan
Format: Article
Language:English
Subjects:
Acicular nanorods
Biological and medical sciences
Biosensing Techniques
Biotechnology
Blood Glucose - analysis
Chemical bath deposition
Cobalt - chemistry
Cobalt oxide
Diabetes Mellitus - diagnosis
Fluorine - chemistry
Fundamental and applied biological sciences. Psychology
Glucose sensor
Humans
Limit of Detection
Modified electrode
Nanotubes - chemistry
Non-enzymatic detection
Oxides - chemistry
Sensitivity and Specificity
Tin Compounds - chemistry
X-Ray Diffraction
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Summary:Acicular cobalt oxide nanorods (CoONRs) were prepared for the non-enzymatic detection of glucose, first by directly growing layered cobalt carbonate hydroxide (LCCH) on a conducting fluorine-doped tin oxide (FTO) substrate using a simple chemical bath deposition (CBD) technique and then by transforming the LCCH into CoONRs through pyrolysis. The composition and grain size of the films of LCCH and CoONRs were verified by X-ray diffraction (XRD); their morphologies were examined by scanning electron microscopic (SEM) and transmission electron microscopic (TEM) images. CoONRs showed high electrocatalytic activity for the electro-oxidation of glucose in alkaline media, and the activity was strongly influenced by NaOH concentration, annealing temperature of CoONRs, and thickness of CoONRs film. The pertinent sensor could be successfully used for the quantification of glucose by amperometric method. The sensing parameters include wide linear range up to 3.5 mM, a high sensitivity of 571.8 μA/(cm 2 mM), and a remarkable low detection limit of 0.058 μM. The CoONRs modified electrode exhibited a high selectivity for glucose in human serum, against ascorbic acid, uric acid, and acetaminophen.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2011.06.033