Angiogenesis inhibition by a lichen compound olivetoric acid

Lichens have been used in folk medicine for centuries and are symbiotic organisms of fungi and algae that produce unique secondary metabolites. Olivetoric acid is one of these secondary metabolites. In the present study, the effect of olivetoric acid isolated from acetone extract of the lichen Pseud...

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Bibliographic Details
Published in:Phytotherapy research 2010-05, Vol.24 (5), p.754-758
Main Authors: Koparal, A. Tansu, Ulus, Gönül, Zeytinoğlu, Melih, Tay, Turgay, Türk, Ayşen Özdemir
Format: Article
Language:English
Subjects:
Acetone
Actin
Actins - drug effects
Adipose tissue
Adipose Tissue - cytology
Algae
Angiogenesis
Angiogenesis Inhibitors - isolation & purification
Angiogenesis Inhibitors - pharmacology
Animals
anti-angiogenic
Biological and medical sciences
Cell Proliferation
Cells, Cultured
Cytoskeleton
Depolymerization
Endothelial cells
Endothelial Cells - drug effects
Fibers
Fungi
General pharmacology
Lichens
Lichens - chemistry
Medical sciences
olivetoric acid
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Pseudevernia furfuracea
Rats
Salicylates - isolation & purification
Salicylates - pharmacology
Secondary metabolites
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Summary:Lichens have been used in folk medicine for centuries and are symbiotic organisms of fungi and algae that produce unique secondary metabolites. Olivetoric acid is one of these secondary metabolites. In the present study, the effect of olivetoric acid isolated from acetone extract of the lichen Pseudevernia furfuracea (var. ceratea) on angiogenesis was evaluated. It displayed potent anti-angiogenic activities in vitro: inhibited proliferation of rat adipose tissue endothelial cells (RATECs) and disrupted endothelial tube formation in a dose-dependent manner. Furthermore, dose-dependent depolymerization effects of olivetoric acid on F-actin stress fibers were observed. Decrease in the tube formation of RATECs by olivetoric acid might be explained by a disorganization of the actin cytoskeleton. These findings suggest that olivetoric acid is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.3035