An efficient green chemical approach for the synthesis of structurally diverse spiroheterocycles with fused heterosystems

Structurally diverse spiroheterocycles with fused heterosystems; spiro[benzothiazolo[2,3-b] chromeno[3,4-e]pyrimidine-7,3[prime or minute]-indoline]-2[prime or minute],6-diones, spiro[benzothiazolo[2,3-b]pyrimido[5,4-e]pyrimidine-5,3[prime or minute]-indoline]-2,2[prime or minute],4-triones, spiro[b...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2011-01, Vol.13 (5), p.1332-1338
Main Authors: KUMAR ARYA, Anand, KUMAR, Mahendra
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Organic chemistry
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:Structurally diverse spiroheterocycles with fused heterosystems; spiro[benzothiazolo[2,3-b] chromeno[3,4-e]pyrimidine-7,3[prime or minute]-indoline]-2[prime or minute],6-diones, spiro[benzothiazolo[2,3-b]pyrimido[5,4-e]pyrimidine-5,3[prime or minute]-indoline]-2,2[prime or minute],4-triones, spiro[benzothiazolo[2,3-b]quinazolin-5,3[prime or minute]-indoline]-2[prime or minute],4-diones and spiro[benzothiazolo[2,3-b]pyrano[3,4-e]pyrimidine-5,3[prime or minute]-indoline]-2[prime or minute],4-diones incorporating medicinally privileged heterosystems have been synthesized by an environmentally benign, efficient and convenient synthesis involving the sulfamic acid-catalyzed multicomponent domino reaction of 2-aminobenzothiazoles with isatin and cyclic 1,3-diketones in an aqueous medium.
ISSN:1463-9262
1463-9270
DOI:10.1039/c1gc00008j