Detection of TFPI2 methylation in the serum of colorectal cancer patients

Highlights ► Thirty-nine of 215 patients exhibited TFPI2 methylation in their serum DNA. ► TFPI2 methylation was observed more frequently according to the cancer progression. ► Using three serum markers including TFPI2 methylation, the detection rate was 42%.

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Bibliographic Details
Published in:Cancer letters 2011-12, Vol.311 (1), p.96-100
Main Authors: Hibi, Kenji, Goto, Tetsuhiro, Shirahata, Atsushi, Saito, Mitsuo, Kigawa, Gaku, Nemoto, Hiroshi, Sanada, Yutaka
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Biomarkers, Tumor - genetics
blood serum
carcinoma
Cell Differentiation
Colorectal cancer
colorectal neoplasms
Colorectal Neoplasms - blood
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Deoxyribonucleic acid
DNA
DNA Methylation
Female
Gene expression
Genetic testing
Glycoproteins - genetics
Hematology, Oncology and Palliative Medicine
Humans
lymph nodes
Male
metastasis
Methylation
Middle Aged
Mitochondrial DNA
patients
polymerase chain reaction
screening
Studies
TFPI2
Tumors
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Description
Summary:Highlights ► Thirty-nine of 215 patients exhibited TFPI2 methylation in their serum DNA. ► TFPI2 methylation was observed more frequently according to the cancer progression. ► Using three serum markers including TFPI2 methylation, the detection rate was 42%.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.07.006