Synthesis, Characterization and DNA-binding Properties of Ln(III) Complexes with 6-Ethoxy Chromone-3-Carbaldehyde Benzoyl Hydrazone

A novel 6-ethoxy chromone-3-carbaldehyde benzoyl hydrazone (L) and its Ln(III) complexes, [Ln = Sm ( 1 ), Eu ( 2 ), Gd ( 3 ), Tb ( 4 )], have been synthesized and characterized. The fluorescence properties of the Eu(III) and Sm(III) complexes in solid state and Eu(III) complex in different solutions...

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Bibliographic Details
Published in:Journal of fluorescence 2009-09, Vol.19 (5), p.847-856
Main Authors: Wang, Ju, Yang, Zheng-Yin, Wang, Bao-Dui, Yi, Xu-Yang, Liu, Yong-Chun
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Acetonitrile
Acetonitriles - chemistry
Analytical Chemistry
Animals
Antioxidants - chemical synthesis
Antioxidants - chemistry
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedicine
Biophysics
Biotechnology
Cattle
Chromones - chemistry
Dimethyl Sulfoxide - chemistry
Dimethylformamide
DNA - chemistry
Fluorescence
Formamides - chemistry
Free Radical Scavengers - chemistry
Free radicals
Hydrazones
Hydrazones - chemistry
Lanthanoid Series Elements - chemistry
Methanol - chemistry
Methyl alcohol
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Original Paper
Spectrometry, Fluorescence
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Synthesis
Viscosity
Viscosity measurement
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Summary:A novel 6-ethoxy chromone-3-carbaldehyde benzoyl hydrazone (L) and its Ln(III) complexes, [Ln = Sm ( 1 ), Eu ( 2 ), Gd ( 3 ), Tb ( 4 )], have been synthesized and characterized. The fluorescence properties of the Eu(III) and Sm(III) complexes in solid state and Eu(III) complex in different solutions (DMF, DMSO, methanol and acetonitrile) were investigated. At the same time, the DNA-binding properties of the two complexes are investigated using UV-Vis absorption spectroscopy, fluorescence spectroscopy, viscosity measurement. All the experimental evidences indicate that the two complexes can bind to CT-DNA via an intercalation mechanism. Furthermore, antioxidant activity tests in vitro showed that the complexes have significant antioxidative activity against hydroxyl free radicals from the Fenton reaction.
ISSN:1053-0509
1573-4994
DOI:10.1007/s10895-009-0482-y