Histone ADP-ribosylation in DNA repair, replication and transcription

Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ri...

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Bibliographic Details
Published in:Trends in cell biology 2011-09, Vol.21 (9), p.534-542
Main Authors: Messner, Simon, Hottiger, Michael O
Format: Article
Language:English
Subjects:
Adenosine Diphosphate Ribose - metabolism
ADP Ribose Transferases - metabolism
Animals
Cell Cycle
Chromatin - metabolism
Chromatin Assembly and Disassembly
DNA Repair
DNA Replication
Histones - metabolism
Humans
Pathology
Phosphorylation
Protein Processing, Post-Translational
Transcription, Genetic
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Summary:Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has often been restricted to functions of the modifying enzymes, rather than to histones as ADP-ribose acceptors. In particular, the identification of specific lysine residues as ADP-ribose acceptor sites in histones and the identification of ADP-ribose binding modules raise this modification to a par with acetylation, methylation or phosphorylation. We discuss here the functional aspects of histone ADP-ribosylation and its influence on DNA repair, replication and transcription.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2011.06.001