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Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease
Background Gammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn’s-like colitis in mice. Aims The aim of this study was to measure the γδ T lymphocyte levels in Crohn’s disease (CD) patients. Methods A prospective s...
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| Published in: | Digestive diseases and sciences 2011-09, Vol.56 (9), p.2613-2622 |
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| container_title | Digestive diseases and sciences |
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| creator | Andreu-Ballester, Juan Carlos Amigó-García, Victoria Catalán-Serra, Ignacio Gil-Borrás, Rafael Ballester, Ferrán Almela-Quilis, Amadeo Millan-Scheiding, Monica Peñarroja-Otero, Carlos |
| description | Background
Gammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn’s-like colitis in mice.
Aims
The aim of this study was to measure the γδ T lymphocyte levels in Crohn’s disease (CD) patients.
Methods
A prospective study of 40 patients with CD compared with 40 healthy subjects (control group) matched by age and sex was undertaken. Lennard-Jones criteria were used for the diagnosis of CD. Disease activity was measured with the Crohn’s disease activity index (CDAI). New patients, patients in remission, and patients with active disease were evaluated. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, CD19+, and αβ and γδ subsets were measured in the peripheral blood of all participants.
Results
The levels of CD3+, CD4+, CD8+, and CD19+ lymphocytes were decreased in CD patients compared with the control group (
P
= 0.002, 0.049, 0.003, and 0.023, respectively). Although both γδ and αβ T lymphocytes were lower in patients with CD, γδ T subsets showed the lowest levels in CD patients (mean 0.0259 × 10
9
/l) versus healthy controls (mean 0.0769 × 10
9
/l),
P
|
| doi_str_mv | 10.1007/s10620-011-1636-8 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_907179880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712950253</galeid><sourcerecordid>A712950253</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-c7b83662e9a5144ca4143b72b5602b722c6059a453672e8599f0a2a865c9ce303</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhiMEotvCA3BBFqjilOKxY8c-tlsoSCvRQ7lieb2TxlUSL3ZWaG-8Bq_Hk-AoCxUIhHwYafz9Y4--ongG9AworV8noJLRkgKUILks1YNiAaLmJRNSPSwWNHdLBiCPiuOU7iilugb5uDhiwOuKympRfLrExjs_ktCQK9v3doPdaMkNWe37bRvcfsRE_EDGFsk1Rr9tMdqOXHQhbKbMtR09DmMiX_zYkmUM7fD967dELn1Cm_BJ8aixXcKnh3pSfHz75mb5rlx9uHq_PF-VrtJ6LF29VlxKhtoKqCpnK6j4umZrISnLlTlJhbaV4LJmqITWDbXMKimcdsgpPylezXO3MXzeYRpN75PDrrMDhl0ymtZQa6X-TyqleAVCi0y--IO8C7s45DUmCDhIKjP0coZubYfGD00Yo3XTSHNeA9OCMsEzdfYXKp8N9t6FITvI_d8CMAdcDClFbMw2-t7GvQFqJvdmdm-yezO5Nypnnh_-u1v3uPmV-Ck7A6cHwCZnuybawfl0z1USsoNpcTZzKV8NtxjvF__36z8AD5LCpQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>888131606</pqid></control><display><type>article</type><title>Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease</title><source>Springer Link</source><creator>Andreu-Ballester, Juan Carlos ; Amigó-García, Victoria ; Catalán-Serra, Ignacio ; Gil-Borrás, Rafael ; Ballester, Ferrán ; Almela-Quilis, Amadeo ; Millan-Scheiding, Monica ; Peñarroja-Otero, Carlos</creator><creatorcontrib>Andreu-Ballester, Juan Carlos ; Amigó-García, Victoria ; Catalán-Serra, Ignacio ; Gil-Borrás, Rafael ; Ballester, Ferrán ; Almela-Quilis, Amadeo ; Millan-Scheiding, Monica ; Peñarroja-Otero, Carlos</creatorcontrib><description>Background
Gammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn’s-like colitis in mice.
Aims
The aim of this study was to measure the γδ T lymphocyte levels in Crohn’s disease (CD) patients.
Methods
A prospective study of 40 patients with CD compared with 40 healthy subjects (control group) matched by age and sex was undertaken. Lennard-Jones criteria were used for the diagnosis of CD. Disease activity was measured with the Crohn’s disease activity index (CDAI). New patients, patients in remission, and patients with active disease were evaluated. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, CD19+, and αβ and γδ subsets were measured in the peripheral blood of all participants.
Results
The levels of CD3+, CD4+, CD8+, and CD19+ lymphocytes were decreased in CD patients compared with the control group (
P
= 0.002, 0.049, 0.003, and 0.023, respectively). Although both γδ and αβ T lymphocytes were lower in patients with CD, γδ T subsets showed the lowest levels in CD patients (mean 0.0259 × 10
9
/l) versus healthy controls (mean 0.0769 × 10
9
/l),
P
< 0.001. In particular, γδ CD8+ T subsets (mean 0.0068 × 10
9
/l) had the largest difference compared to the control group (mean 0.0199 × 10
9
/l),
P
= 0.008.
Conclusions
There is a decrease in the global lymphocyte population in the peripheral blood of patients with CD compared to healthy controls. This decrease is more evident in γδ T lymphocytes, especially γδ CD8+ T subsets. Our conclusion is that these results support the theory that a complex alteration of immune responses that affects the total numbers and function of γδ T cells is present in CD.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-011-1636-8</identifier><identifier>PMID: 21374064</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Antigens, CD - metabolism ; Biochemistry ; Biological and medical sciences ; Case-Control Studies ; Colitis ; Comparative analysis ; Crohn Disease - blood ; Crohn Disease - drug therapy ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Humans ; Immunity, Innate ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Male ; Medical research ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Oncology ; Original Article ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; T cells ; T-Lymphocyte Subsets - metabolism ; Transplant Surgery ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2011-09, Vol.56 (9), p.2613-2622</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-c7b83662e9a5144ca4143b72b5602b722c6059a453672e8599f0a2a865c9ce303</citedby><cites>FETCH-LOGICAL-c499t-c7b83662e9a5144ca4143b72b5602b722c6059a453672e8599f0a2a865c9ce303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24616625$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21374064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andreu-Ballester, Juan Carlos</creatorcontrib><creatorcontrib>Amigó-García, Victoria</creatorcontrib><creatorcontrib>Catalán-Serra, Ignacio</creatorcontrib><creatorcontrib>Gil-Borrás, Rafael</creatorcontrib><creatorcontrib>Ballester, Ferrán</creatorcontrib><creatorcontrib>Almela-Quilis, Amadeo</creatorcontrib><creatorcontrib>Millan-Scheiding, Monica</creatorcontrib><creatorcontrib>Peñarroja-Otero, Carlos</creatorcontrib><title>Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Gammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn’s-like colitis in mice.
Aims
The aim of this study was to measure the γδ T lymphocyte levels in Crohn’s disease (CD) patients.
Methods
A prospective study of 40 patients with CD compared with 40 healthy subjects (control group) matched by age and sex was undertaken. Lennard-Jones criteria were used for the diagnosis of CD. Disease activity was measured with the Crohn’s disease activity index (CDAI). New patients, patients in remission, and patients with active disease were evaluated. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, CD19+, and αβ and γδ subsets were measured in the peripheral blood of all participants.
Results
The levels of CD3+, CD4+, CD8+, and CD19+ lymphocytes were decreased in CD patients compared with the control group (
P
= 0.002, 0.049, 0.003, and 0.023, respectively). Although both γδ and αβ T lymphocytes were lower in patients with CD, γδ T subsets showed the lowest levels in CD patients (mean 0.0259 × 10
9
/l) versus healthy controls (mean 0.0769 × 10
9
/l),
P
< 0.001. In particular, γδ CD8+ T subsets (mean 0.0068 × 10
9
/l) had the largest difference compared to the control group (mean 0.0199 × 10
9
/l),
P
= 0.008.
Conclusions
There is a decrease in the global lymphocyte population in the peripheral blood of patients with CD compared to healthy controls. This decrease is more evident in γδ T lymphocytes, especially γδ CD8+ T subsets. Our conclusion is that these results support the theory that a complex alteration of immune responses that affects the total numbers and function of γδ T cells is present in CD.</description><subject>Adult</subject><subject>Antigens, CD - metabolism</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Colitis</subject><subject>Comparative analysis</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - drug therapy</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>T cells</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Transplant Surgery</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkcFu1DAQhiMEotvCA3BBFqjilOKxY8c-tlsoSCvRQ7lieb2TxlUSL3ZWaG-8Bq_Hk-AoCxUIhHwYafz9Y4--ongG9AworV8noJLRkgKUILks1YNiAaLmJRNSPSwWNHdLBiCPiuOU7iilugb5uDhiwOuKympRfLrExjs_ktCQK9v3doPdaMkNWe37bRvcfsRE_EDGFsk1Rr9tMdqOXHQhbKbMtR09DmMiX_zYkmUM7fD967dELn1Cm_BJ8aixXcKnh3pSfHz75mb5rlx9uHq_PF-VrtJ6LF29VlxKhtoKqCpnK6j4umZrISnLlTlJhbaV4LJmqITWDbXMKimcdsgpPylezXO3MXzeYRpN75PDrrMDhl0ymtZQa6X-TyqleAVCi0y--IO8C7s45DUmCDhIKjP0coZubYfGD00Yo3XTSHNeA9OCMsEzdfYXKp8N9t6FITvI_d8CMAdcDClFbMw2-t7GvQFqJvdmdm-yezO5Nypnnh_-u1v3uPmV-Ck7A6cHwCZnuybawfl0z1USsoNpcTZzKV8NtxjvF__36z8AD5LCpQ</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Andreu-Ballester, Juan Carlos</creator><creator>Amigó-García, Victoria</creator><creator>Catalán-Serra, Ignacio</creator><creator>Gil-Borrás, Rafael</creator><creator>Ballester, Ferrán</creator><creator>Almela-Quilis, Amadeo</creator><creator>Millan-Scheiding, Monica</creator><creator>Peñarroja-Otero, Carlos</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110901</creationdate><title>Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease</title><author>Andreu-Ballester, Juan Carlos ; Amigó-García, Victoria ; Catalán-Serra, Ignacio ; Gil-Borrás, Rafael ; Ballester, Ferrán ; Almela-Quilis, Amadeo ; Millan-Scheiding, Monica ; Peñarroja-Otero, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-c7b83662e9a5144ca4143b72b5602b722c6059a453672e8599f0a2a865c9ce303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Antigens, CD - metabolism</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Colitis</topic><topic>Comparative analysis</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - drug therapy</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>T cells</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Transplant Surgery</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andreu-Ballester, Juan Carlos</creatorcontrib><creatorcontrib>Amigó-García, Victoria</creatorcontrib><creatorcontrib>Catalán-Serra, Ignacio</creatorcontrib><creatorcontrib>Gil-Borrás, Rafael</creatorcontrib><creatorcontrib>Ballester, Ferrán</creatorcontrib><creatorcontrib>Almela-Quilis, Amadeo</creatorcontrib><creatorcontrib>Millan-Scheiding, Monica</creatorcontrib><creatorcontrib>Peñarroja-Otero, Carlos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andreu-Ballester, Juan Carlos</au><au>Amigó-García, Victoria</au><au>Catalán-Serra, Ignacio</au><au>Gil-Borrás, Rafael</au><au>Ballester, Ferrán</au><au>Almela-Quilis, Amadeo</au><au>Millan-Scheiding, Monica</au><au>Peñarroja-Otero, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>56</volume><issue>9</issue><spage>2613</spage><epage>2622</epage><pages>2613-2622</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background
Gammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn’s-like colitis in mice.
Aims
The aim of this study was to measure the γδ T lymphocyte levels in Crohn’s disease (CD) patients.
Methods
A prospective study of 40 patients with CD compared with 40 healthy subjects (control group) matched by age and sex was undertaken. Lennard-Jones criteria were used for the diagnosis of CD. Disease activity was measured with the Crohn’s disease activity index (CDAI). New patients, patients in remission, and patients with active disease were evaluated. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, CD19+, and αβ and γδ subsets were measured in the peripheral blood of all participants.
Results
The levels of CD3+, CD4+, CD8+, and CD19+ lymphocytes were decreased in CD patients compared with the control group (
P
= 0.002, 0.049, 0.003, and 0.023, respectively). Although both γδ and αβ T lymphocytes were lower in patients with CD, γδ T subsets showed the lowest levels in CD patients (mean 0.0259 × 10
9
/l) versus healthy controls (mean 0.0769 × 10
9
/l),
P
< 0.001. In particular, γδ CD8+ T subsets (mean 0.0068 × 10
9
/l) had the largest difference compared to the control group (mean 0.0199 × 10
9
/l),
P
= 0.008.
Conclusions
There is a decrease in the global lymphocyte population in the peripheral blood of patients with CD compared to healthy controls. This decrease is more evident in γδ T lymphocytes, especially γδ CD8+ T subsets. Our conclusion is that these results support the theory that a complex alteration of immune responses that affects the total numbers and function of γδ T cells is present in CD.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21374064</pmid><doi>10.1007/s10620-011-1636-8</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2011-09, Vol.56 (9), p.2613-2622 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | Springer Link |
| subjects | Adult Antigens, CD - metabolism Biochemistry Biological and medical sciences Case-Control Studies Colitis Comparative analysis Crohn Disease - blood Crohn Disease - drug therapy Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Immunity, Innate Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Male Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Middle Aged Oncology Original Article Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus T cells T-Lymphocyte Subsets - metabolism Transplant Surgery Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease |
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