Protein translation in Plasmodium parasites

The protein translation machinery of the parasite Plasmodium is the target of important anti-malarial drugs, and encompasses many promising targets for future drugs. Plasmodium parasites have three subcellular compartments that house genomes; the nucleus, mitochondrion and apicoplast, and each requi...

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Bibliographic Details
Published in:Trends in parasitology 2011-10, Vol.27 (10), p.467-476
Main Authors: Jackson, Katherine E, Habib, Saman, Frugier, Magali, Hoen, Rob, Khan, Sameena, Pham, James S, Pouplana, Lluís Ribas de, Royo, Miriam, Santos, Manuel A.S, Sharma, Amit, Ralph, Stuart A
Format: Article
Language:English
Subjects:
Amino Acyl-tRNA Synthetases - metabolism
antimalarials
Antimalarials - pharmacology
Biological and medical sciences
Cell Nucleus - genetics
Cell Nucleus - metabolism
drugs
Gastroenterology and Hepatology
Gene Expression Regulation
General aspects
Genes, Protozoan
genome
Genome, Mitochondrial
Humans
Infectious Disease
Infectious diseases
Malaria - drug therapy
Malaria - parasitology
Medical sciences
Mitochondria - drug effects
Mitochondria - genetics
Mitochondria - metabolism
nucleotide sequences
organelles
parasites
Parasitic diseases
parasitology
Plasmodium
Plasmodium - drug effects
Plasmodium - genetics
Plasmodium - growth & development
Plasmodium - metabolism
Protein Biosynthesis
Protein Processing, Post-Translational
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Ribosomes - genetics
Ribosomes - metabolism
RNA, Transfer - genetics
RNA, Transfer - metabolism
sequence analysis
transcription (genetics)
translation (genetics)
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Summary:The protein translation machinery of the parasite Plasmodium is the target of important anti-malarial drugs, and encompasses many promising targets for future drugs. Plasmodium parasites have three subcellular compartments that house genomes; the nucleus, mitochondrion and apicoplast, and each requires its own compartmentalized transcription and translation apparatus for survival. Despite the availability of the complete genome sequence that should reveal the requisite elements for all three compartments, our understanding of the translation machineries is patchy. We review what is known about cytosolic and organellar translation in Plasmodium and discuss the molecules that have been identified through genome sequencing and post-genomic analysis. Some translation components are yet to be found in Plasmodium , whereas others appear to be shared between translationally active organelles.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2011.05.005