Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)

Highlights ► gfPRP/PACAP and PRPR mRNAs co-expressed in the BPG axis. ► gfPRP stimulation utilizes cAMP signaling pathway. ► gfPRP is unable to stimulate GH gene expression. ► gfPRP alters reproductive hormones gene expression in the BPG axis.

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Bibliographic Details
Published in:General and comparative endocrinology 2011-09, Vol.173 (3), p.405-410
Main Authors: Tam, Janice K.V, Lee, Leo T.O, Cheng, Christopher H.K, Chow, Billy K.C
Format: Article
Language:English
Subjects:
amphibians
animal ovaries
Animals
brain
Brain - metabolism
Carassius auratus
Endocrinology & Metabolism
Female
Fish Proteins - genetics
Fish Proteins - metabolism
Fish Proteins - physiology
follicle-stimulating hormone
Follicle-stimulating hormone (FSH)
Freshwater
gene expression
genes
Goldfish
Goldfish - genetics
Goldfish - metabolism
Goldfish - physiology
gonadotropin-releasing hormone
Growth hormone (GH)
luteinizing hormone
Luteinizing hormone (LH)
Male
mammals
messenger RNA
PACAP-related peptide (PRP)
Peptide Fragments - genetics
Peptide Fragments - metabolism
Peptide Fragments - physiology
Pituitary adenylate cyclase-activating polypeptide (PACAP)
Pituitary Adenylate Cyclase-Activating Polypeptide - genetics
Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism
Pituitary Adenylate Cyclase-Activating Polypeptide - physiology
Pituitary Gland - metabolism
polypeptides
Protein Precursors - genetics
Protein Precursors - metabolism
Protein Precursors - physiology
reproduction
RNA, Messenger - metabolism
salmon
Salmonidae
somatoliberin
somatotropin
Teleostei
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Description
Summary:Highlights ► gfPRP/PACAP and PRPR mRNAs co-expressed in the BPG axis. ► gfPRP stimulation utilizes cAMP signaling pathway. ► gfPRP is unable to stimulate GH gene expression. ► gfPRP alters reproductive hormones gene expression in the BPG axis.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2011.06.003