Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide

We found that Hoogsteen base pairs were stabilized by molecular crowding and a histone H3-mimicking peptide, which was not observed for Watson-Crick base pairs. Our findings demonstrate that the type of DNA base pair is critical for the interaction between DNA and histones.

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (10), p.2790-2792
Main Authors: Pramanik, Smritimoy, Nakamura, Kaori, Usui, Kenji, Nakano, Shu-ichi, Saxena, Sarika, Matsui, Jun, Miyoshi, Daisuke, Sugimoto, Naoki
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Pairing
Base Sequence
Binding Sites
DNA - chemistry
DNA - genetics
DNA - metabolism
Histones - chemistry
Histones - metabolism
Molecular Sequence Data
Nucleic Acid Denaturation
Peptides - chemistry
Peptides - metabolism
Protein Binding
Thermodynamics
Transition Temperature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We found that Hoogsteen base pairs were stabilized by molecular crowding and a histone H3-mimicking peptide, which was not observed for Watson-Crick base pairs. Our findings demonstrate that the type of DNA base pair is critical for the interaction between DNA and histones.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc05776b